Lomocycline 250 Capsule
Tetracycline Hydrochloride
250mg
Lomus Pharmaceutical Pvt. Ltd.
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Available as:
Indications
Lomocycline 250 Capsule is used for:
Acne, Lyme disease, Uncomplicated gonorrhea, Syphilis, Psittacosis, Q fever, Pleural effusions, Rocky Mountain spotted fever, Lymphogranuloma venereum, Mycoplasma pneumoniae, Trachoma, Nongonococcal urethritis
Adult Dose
Oral
Susceptible infections
Adult: 250-500 mg 6 hrly. Max: 4 g/day.
Acne
Adult: 250-500 mg daily, in divided doses, for at least 3 mth.
Syphilis
Adult: 500 mg 4 times daily for 15 days.
Gonorrhoea
Adult: 500 mg 4 times daily for 7 days.
Vibrio Cholera
Adult: 500 mg 4 times daily for 3 days
Brucellosis
Adult: 500 mg 4 times daily for 3 wk in combination w/ streptomycin.
Hepatic impairment: Max: 1 g daily.
Child Dose
Oral
Children :
<8 years: Not recommended
>8 y: 25–50 mg/kg/day q6h
not to exceed 3 g/day
Renal Dose
Renal impairment
CrCl 50-80 mL/min: Dose frequency q8-12hr
CrCl 10-50 mL/min: Dose frequency q12-24hr
CrCl <10 mL/min: Dose frequency q24hr
Administration
Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals w/ a full glass of water, in upright position. May be taken w/ meals to reduce GI discomfort.
Contra Indications
Hypersensitivity; pregnancy, lactation, children; renal impairment.
Precautions
Patient w/ pre-existing SLE, myasthenia gravis. Hepatic and mild to moderate renal impairment. Pregnancy. Patient Counselling Avoid direct exposure to sunlight or UV light. Monitoring Parameters Monitor renal, hepatic and haematologic function test, temp, WBC, cultures and sensitivity, appetite, mental status.
Pregnancy-Lactation
Interactions
Impaired absorption w/ antacids containing divalent and trivalent cations (e.g. Al, Ca, Mg), Fe, Zn and Na bicarbonate preparations, kaolin-pectin, bismuth subsalicylate, sucralfate, strontium ranelate, colestipol and colestyramine. May interfere w/ the bactericidal action of penicillin. May potentiate the effect of anticoagulants. May decrease efficacy of oral contraceptives. Nephrotoxic effects may be exacerbated by diuretics or other nephrotoxic drugs. May increase the hypoglycaemic effect of insulin and sulfonylureas in patients w/ DM. May increase toxic effects of ergot alkaloids and methotrexate.
Potentially Fatal: Concurrent methoxyflurane may result to fatal renal toxicity. Increased risk of benign intracranial HTN w/ vit A or retinoids (e.g. acitretin,isotretinoin, tretinoin).
Adverse Effects
Side effects of Tetracycline Hydrochloride :
>10%
Discoloration of teeth and enamel hypoplasia (young children)
1-10%
Diarrhea,Nausea,Photosensitivity
<1%
Anorexia,Abdominal cramps,Antibiotic-associated pseudomembranous colitis,Bulging fontanels in infants,Diabetes insipidus syndrome,Esophagitis,Exfoliative dermatitis,Incr ICP,Pericarditis,Pseudotumor cerebri,Pancreatitis,Pruritus,Pigmentation of nails,Vomiting
Potentially Fatal: Anaphylaxis, hepatotoxicity, nephrotoxicity, blood dyscrasias.
Mechanism of Action
Tetracycline exhibits its bacteriostatic action by reversibly binding to the 30S subunits of the ribosome, thus preventing protein synthesis and arresting cell growth. It has a broad spectrum of antimicrobial activity including Chlamydiaceae, Mycoplasma spp., Rickettsia spp., spirochaetes, many aerobic and anaerobic gm+ve and gm-ve pathogenic bacteria and some protozoa.
Note
Lomocycline 250 250mg Capsule manufactured by Lomus Pharmaceutical Pvt. Ltd.. Its generic name is Tetracycline Hydrochloride. Lomocycline 250 is availble in Nepal.
Farmaco Nepal drug index information on Lomocycline 250 Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.