Lomotil Tablet
Diphenoxylate + Atropine
RPG Life Sciences Ltd.
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| Retail Price | 1.06 NPR |
Indications
Lomotil Tablet is used for:
Diarrhoea
Adult Dose
Oral
Diarrhoea
Adult: Each tab or 5 mL soln contains diphenoxylate HCl 2.5 mg and atropine sulphate 0.025 mg: Initially, 5 mg 4 times daily, may reduce dose to 5 mg daily once satisfactory control is achieved. Max: 20 mg daily.
Child Dose
Oral
Diarrhoea
Child: As oral soln: Recommended dose: 2 yr 1.5-3 mL. 3 yr 2-3 mL. 4 yr 2-4 mL. 5 yr 2.5-4.5 mL. 6-8 yr 2.5-5 mL. 9-12 yr 3.5-5 mL. Dose is given 4 times daily.
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Jaundice, intestinal obstruction, acute ulcerative colitis, raised intracranial pressure, head injury, myasthenia gravis, pyloric stenosis, paralytic ileus, prostatic enlargement. Childn <2 yr.
Precautions
Patient w/ history of physical dependence, cirrhosis or advanced hepatorenal disease. Hepatic and renal impairment. Childn. Pregnancy and lactation. Not indicated as treatment for diarrhoea associated w/ pseudomembranous colitis or enterotoxin-producing bacteria.
Pregnancy-Lactation
Interactions
Increased antimuscarinic side effects w/ amantadine, antihistamines, and TCAs. Antagonises the effect of domperidone, metoclopramide, bethanechol, carbachol, cisapride, galantamine, neostigomine, pyridostigmine, and pilocarpine. May potentiate CNS depressant effects of barbiturates and tranquilizers. May precipitate hypertensive crisis when concomitantly used w/ MAOIs. May reduce absorption of ketoconazole. May reduce plasma concentration of levodopa. Increased effect w/ memantine.
Adverse Effects
Side effects of Diphenoxylate + Atropine :
1-10%
Anticholinergic effects
Blurred vision
Sedation
Nausea
Vomiting
Abdominal discomfort
Dryness of skin or mouth
Frequency Not Defined
Pancreatitis
Toxic megacolon
Mechanism of Action
Diphenoxylate: Acts on smooth muscle of intestinal tract, inhibiting GI motility and excessive GI propulsion (like morphine)
Atropine: Subtherapeutic quantity of atropine is added to discourage deliberate overdose of diphenoxylate
Note
Lomotil Tablet manufactured by RPG Life Sciences Ltd.. Its generic name is Diphenoxylate + Atropine. Lomotil is availble in Nepal.
Farmaco Nepal drug index information on Lomotil Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.