Lonid Tablet
Clonidine Hydrochloride
150mcg
Magnus Pharma Pvt. Ltd.
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 2.00 NPR |
Indications
Lonid Tablet is used for:
Hypertension, Anxiety disorders, Migraine, Panic disorder, Menopausal flushing, Hypertensive crisis, Cancer pain
Adult Dose
Oral
Hypertension
Adult: Initially, 50-100 mcg tid, increased every 2nd or 3rd day according to response.
Maintenance: 300-1,200 mcg daily, some may require >1,800 mcg daily. Max: 2,400 mcg daily.
Prophylaxis of migraine; Menopausal flushing
Adult: 50 mcg bid, increased to 75 mcg bid if no remission after 2 wk.
Child Dose
<12 years old: Safety and efficacy not established
Renal Dose
Renal impairment: Supplemental doses after haemodialysis are not necessary.
CrCl (ml/min)
<10 50-75% of usual dose.
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity. Disorders of cardiac pacemaker activity and conduction. Pregnancy and lactation.
Precautions
Withdraw gradually, renal impairment, tasks that require mental alertness. Cerebrovascular disease, ischaemic heart disease, MI. IV inj should be administered slowly. Occlusive peripheral vascular disorders, history of depression.
Lactation: Distributed in breast milk; caution advised
Pregnancy-Lactation
Interactions
Hypotensive action may be potentiated by diuretics and vasodilators. Effects of clonidine antagonised by TCAs and centrally-acting alpha-blockers. May enhance toxicity due to digitalis, lithium. May antagonise oral hypoglycaemics.
Potentially Fatal: Hypnosedatives, antihistamines and alcohol may cause excessive drowsiness in patients on clonidine. Withdrawal of clonidine in patients receiving noncardioselective ?-blockers may result in rebound BP. Acute severe hypotension following concomitant administration of clonidine and chlorpromazine or haloperidol.
Adverse Effects
Side effects of Clonidine Hydrochloride :
>10%
Skin reactions; patch (15-50%),Dry mouth (40%),Somnolence (19-38%),Headache (19-29%),Fatigue (13-24%),Drowsiness (33%),Dizziness (13-16%),Hypotension, epidural (45%),Postural hypotension, epidural (32%),Anxiety (11%)
1-10%
Constipation (10%),Sedation (10%),Nausea/vomiting, PO (5%),Malaise (3%),Orthostatic hypotension (3%),Anorexia, PO (1%),Abnormal LFTs (1%),Rash (1%),Weight gain, PO (1%)
Frequency Not Defined
Children with ADHD
Upper respiratory tract infection,Irritability,Throat pain,Nightmares,Insomnia,Emotional disorder,Constipation,Nasal congestion
Potentially Fatal: Transient hypertension or profound hypotension, respiratory depression, convulsion. Clonidine withdrawal syndrome could be life threatening. Bradycardia, coma and disturbances in conduction (in individuals with preexisting diseases of SA/AV nodes, overdose or on digitalis).
Mechanism of Action
Clonidine stimulates alpha-2 receptors in brain stem which results in reduced sympathetic outflow from the CNS and a decrease in peripheral resistance leading to reduced BP and pulse rate. It does not alter normal haemodynamic response to exercise at recommended dosages.
Note
Lonid 150mcg Tablet manufactured by Magnus Pharma Pvt. Ltd.. Its generic name is Clonidine Hydrochloride. Lonid is availble in Nepal.
Farmaco Nepal drug index information on Lonid Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.