Lotensyl 10 Tablet

Lercanidipine Hydrochloride
10mg
Sun Pharmaceutical Industries Ltd.
Pack size
Dispensing mode
Source
Agent
Retail Price 9.74 NPR

Available as:

Indications

Lotensyl 10 Tablet is used for: Mild to moderate essential hypertension, Stroke prevention.

Adult Dose

Oral Hypertension Adult: As hydrochloride: 10 mg once daily, increased after 2 wk to 20 mg daily if necessary. Elderly: The recommended dosage is 10 mg orally once a day at least 15 minutes before meals; the dose may be increased to 20 mg depending on the individual patient's response. Hepatic impairment: Special care should be exercised in patients with mild to moderate renal or hepatic dysfunction. Dosage above 20 mg daily must be approached with caution. Lercanidipine is not recommended for use in patients with severe hepatic dysfunction.

Child Dose

Renal Dose

Renal impairment: Dosage may need to be reduced in mild to moderate renal impairment. Avoid in patients with CrCl <12 ml/min.

Administration

Should be taken on an empty stomach. Take on an empty stomach at least 15 min before meals.

Contra Indications

Severe hepatic or renal impairment; aortic stenosis, unstable angina, uncontrolled heart failure, within 1 mth of MI; and known hypersensitivity to any dihydropyridine. Lercanidipine should not be taken with grapefruit juice. lactation, pregnancy.

Precautions

Left ventricular dysfunction, sick sinus syndrome (if pacemaker not fitted), left ventricular dysfunction and ischaemic heart disease.

Pregnancy-Lactation

Interactions

Plasma concentration reduced by inducers of CYP3A4 eg rifampicin, phenytoin, carbamazepine. Bioavailability also reduced by metoprolol and possibly propranolol. Plasma concentrations increased by inhibitors of CYP3A4 eg imidazole antifungals, erythromycin, ritonavir, fluoxetine. Alcohol may potentiate vasodilating effect. Potentially Fatal: Significantly increased plasma levels of both lercanidipine and ciclosporin when administered together.

Adverse Effects

Side effects of Lercanidipine Hydrochloride : Tachycardia, oedema, flushing, headache, dizziness, asthenia, rash, diarrhoea, polyuria, palpitations, hypotension, drowsiness, myalgia.

Mechanism of Action

Lercanidipine is a dihydropyridine calcium-channel blocker which acts by inhibiting the influx of calcium ions through the slow channels of the vascular smooth muscle and myocardium during depolarization. Its main effect is vasodilatation because it has greater selectivity for vascular smooth muscle than cardiac smooth muscle.

Note

Lotensyl 10 10mg Tablet manufactured by Sun Pharmaceutical Industries Ltd.. Its generic name is Lercanidipine Hydrochloride. Lotensyl 10 is availble in Nepal. Farmaco Nepal drug index information on Lotensyl 10 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Lercanidipine Hydrochloride :