Loxapac 10 Tablet

Loxapine
10mg
Wyeth
Pack size
Dispensing mode
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Agent
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Indications

Loxapac 10 Tablet is used for: Psychoses, Schizophrenia, Acute psychosis, Acute agitation

Adult Dose

Oral Psychoses, Schizophrenia Adult: Initially, 20-50 mg daily in 2 divided doses, increased over the next 7-10 days to 60-100 mg daily in 2-4 divided doses, according to response. Max: 250 mg daily. Maintenance: Use the lowest effective dose between 20-60 mg daily in divided doses. Intramuscular Acute psychosis Adult: 12.5-50 mg at intervals of 4-6 hr. Dosage and dosing interval may be adjusted based on patient response. Inhalation Acute agitation Adult: In patients w/ schizophrenia or bipolar disorder: 10 mg/24 hr via inhaler device.

Child Dose

Renal Dose

Administration

Oral: Should be taken with food.

Contra Indications

Severe drug-induced CNS depression, coma (oral); current diagnosis or history of asthma, COPD, bronchospasm, or acute resp symptoms (inhalation).

Precautions

Patient w/ decreased GI motility, paralytic ileus, urinary retention, BPH, xerostomia, glaucoma, or visual problems, low WBC count, risk of pneumonia, CV diseases, dehydration, cerebrovascular disease, hypovolaemia, Parkinson's disease; history of extrapyramidal symptoms, drug-induced leucopenia/neutropenia, risk factors for seizures (including those w/ history of seizures, head trauma, brain damage, alcoholism). Not indicated for dementia-related psychosis. Avoid abrupt withdrawal or dose reduction. Pregnancy and lactation. Patient Counselling This drug may cause somnolence, motor and sensory instability, if affected, do not drive or operate machinery. Monitoring Parameters Monitor hyperpyrexia, mental status changes, fever, muscle rigidity and autonomic instability, LFT, serum electrolyte level, menstrual changes, libido, abnormal involuntary movements or parkinsonian sign, tardive dyskinesia, visual changes. Monitor signs and symptoms of bronchospasm after oral inhalation admin.

Pregnancy-Lactation

Interactions

Additive effect w/ other CNS or resp depressants (e.g. benzodiazepines, barbiturates, opioids) leading to excessive sedation and resp depression or resp failure. Loxapine may enhance the effect of anticholinergic drugs (e.g. aclidinium, cimetropium, ipratropium).

Adverse Effects

Side effects of Loxapine : Frequency Not Defined Common Hypotension, Orthostatic hypotension Akathisia, dizziness, drug-induced tardive dystonia, dystonia, extrapyramidal disease, parkinsonian, somnolence, tardive dyskinesia Diminished sweating Constipation, xerostomia Blurred vision Urinary retention Nasal congestion Serious Prolonged QT interval, torsades de pointes Ineffective thermoregulation, heatstroke or hypothermia (rare), neuroleptic malignant syndrome (rare), seizure (rare) Paralytic ileus (rare) Agranulocytosis (rare), disorder of hematopoietic structure (rare), leukopenia (rare), thrombocytopenia (rare) Cholestatic jaundice syndrome (rare) Drug-induced lupus erythematosus, systemic (rare) Priapism (rare)

Mechanism of Action

Loxapine is a tricyclic dibenzoxazepine-derivative antipsychotic agent. It blocks postsynaptic mesolimbic dopamine D1 and D2 receptors in the brain. It also inhibits serotonin 5-HT2 receptors.

Note

Loxapac 10 10mg Tablet manufactured by Wyeth. Its generic name is Loxapine. Loxapac 10 is availble in Nepal. Farmaco Nepal drug index information on Loxapac 10 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Loxapine :