Macalvit Tablet
Calcium + Vitamin D3
500mg + 250IU
Novartis India Ltd.
| Pack size | 15't |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 9.07 NPR |
Available as:
Indications
Macalvit Tablet is used for:
Postmenopausal osteoporosis, Osteoporosis, Osteomalacia/Rickets, Hypoparathyroidism, Latent tetany, Hypocalcaemia, Calcium and vitamin D deficiency, Renal osteodystrophy
Adult Dose
Adult: PO: 1 tab once/twice daily.
Child Dose
Renal Dose
Administration
Should be taken with food.
Contra Indications
Patients with hypercalcaemia and/or hypercalciuria. Nephrolithiasis, hypervitaminosis D, hypophosphataemia.
Precautions
Impaired calcium absorption in achlorhydria which is common in elderly. Increased risk of hypercalcaemia and hypercalciuria in hypoparathyroid patients receiving high doses of vitamin D. Caution when using in patients with history of kidney stones. Renal impairment; frequent monitoring of serum calcium and phosphorus is recommended.
Lactation: Distributed in human breast milk
Supplement calcium and vitamin D during pregnancy and lactation according to recommended daily allowance
Pregnancy-Lactation
Interactions
May affect the absorption of tetracycline when used together. Concurrent use with systemic corticosteroids may reduce calcium absorption. Thiazide diuretics may decrease urinary excretion of calcium. Concurrent use with ion-exchange resins may reduce GI absorption of vitamin D. Hypercalcaemia may increase the toxicity of cardiac glycosides during treatment with calcium and vitamin D, monitor ECG and serum calcium levels. Bisphosphonate or sodium fluoride should be given at least 3 hr before calcium-containing preparations.
Adverse Effects
Side effects of Calcium + Vitamin D3 :
Calcium
Anorexia,Constipation,Flatulence,Nausea,Vomiting,Hypercalcemia,Hypophosphatemia,Xerostomia,Acid rebound,Milk-alkali syndrome
Vitamin D
Hypercalcemia,Muscle/bone pain,Metallic taste,Headache,Nausea,Vomiting,Dry mouth,Constipation,Arrhythmias
Mechanism of Action
Calcium /vitamin D3 prevents or treats negative Ca balance. It also helps facilitate nerve and muscle performance as well as normal cardiac function. Bone mineral component; cofoactor in enzymatic reactions, essential for neurotransmission, muscle contraction, and many signal transduction pathways. Vitamin D3 is a fat-soluble sterol. It is necessary for the regulation and regulation of calcium and phosphate homoeostasis and bone mineralisation.
Vitamin D is also essential for healthy bones as it aids in Calcium absorption from the GI tract. In addition to this it stimulates bone formation. Clinical studies also show that Calcium and Vitamin D has synergistic effects on bone growth as well as in Osteoporosis and fracture prevention.
Note
Macalvit 500mg + 250IU Tablet manufactured by Novartis India Ltd.. Its generic name is Calcium + Vitamin D3. Macalvit is availble in Nepal.
Farmaco Nepal drug index information on Macalvit Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.