Magnamicin 500 Injection

Cefoperazone
500mg
Pfizer Ltd.
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Indications

Magnamicin 500 Injection is used for: Respiratory Tract Infections, Peritonitis and Other Intra-abdominal Infections, Bacterial Septicemia, Infections of the Skin and Skin Structures, Pelvic Inflammatory Disease, Endometritis, and Other Infections of the Female Genital Tract, Urinary Tract Infections

Adult Dose

Parenteral Susceptible infections Adult: As sodium: 2-4 g daily in 2 divided doses, increased to 12 g daily in 2-4 divided doses for severe infections given as deep IM or IV infusion. Hepatic impairment: Max for hepatic impairment or biliary obstruction: 4 g daily. W/ renal impairment: 1-2 g daily.

Child Dose

Renal Dose

Renal impairment: W/ hepatic impairment: 1-2 g daily.

Administration

Contra Indications

Hypersensitivity to cephalosporin.

Precautions

History of penicillin allergy; renal or hepatic impairment; pregnancy, lactation; cystic fibrosis.

Pregnancy-Lactation

Interactions

Disulfiram-like reaction with alcohol. Potentiates anticoagulants. Potentially Fatal: Enhances nephrotoxicity by aminoglycosides and furosemide.

Adverse Effects

Side effects of Cefoperazone : Skin rash, urticaria; eosinophilia, diarrhoea, nausea, vomiting; phloebitis; hypoprothrombinaemia; superinfection. Potentially Fatal: Neuromuscular hypersensitivity; nephrotoxicity.

Mechanism of Action

Cefoperazone binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.

Note

Magnamicin 500 500mg Injection manufactured by Pfizer Ltd.. Its generic name is Cefoperazone. Magnamicin 500 is availble in Nepal. Farmaco Nepal drug index information on Magnamicin 500 Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Cefoperazone :