Magnamicin 500 Injection
Cefoperazone
500mg
Pfizer Ltd.
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Available as:
Indications
Magnamicin 500 Injection is used for:
Respiratory Tract Infections, Peritonitis and Other Intra-abdominal Infections, Bacterial Septicemia, Infections of the Skin and Skin Structures, Pelvic Inflammatory Disease, Endometritis, and Other Infections of the Female Genital Tract, Urinary Tract Infections
Adult Dose
Parenteral
Susceptible infections
Adult: As sodium: 2-4 g daily in 2 divided doses, increased to 12 g daily in 2-4 divided doses for severe infections given as deep IM or IV infusion.
Hepatic impairment: Max for hepatic impairment or biliary obstruction: 4 g daily. W/ renal impairment: 1-2 g daily.
Child Dose
Renal Dose
Renal impairment: W/ hepatic impairment: 1-2 g daily.
Administration
Contra Indications
Hypersensitivity to cephalosporin.
Precautions
History of penicillin allergy; renal or hepatic impairment; pregnancy, lactation; cystic fibrosis.
Pregnancy-Lactation
Interactions
Disulfiram-like reaction with alcohol. Potentiates anticoagulants.
Potentially Fatal: Enhances nephrotoxicity by aminoglycosides and furosemide.
Adverse Effects
Side effects of Cefoperazone :
Skin rash, urticaria; eosinophilia, diarrhoea, nausea, vomiting; phloebitis; hypoprothrombinaemia; superinfection.
Potentially Fatal: Neuromuscular hypersensitivity; nephrotoxicity.
Mechanism of Action
Cefoperazone binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Note
Magnamicin 500 500mg Injection manufactured by Pfizer Ltd.. Its generic name is Cefoperazone. Magnamicin 500 is availble in Nepal.
Farmaco Nepal drug index information on Magnamicin 500 Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.