Magtam Injection
Cefoperazone + Sulbactam
1gm +1gm
Alkem Laboratories Ltd.
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| Retail Price | 395.16 NPR |
Available as:
Indications
Magtam Injection is used for:
Meningitis, Respiratory tract infections, Skin and soft tissue infections, Intra-abdominal infections, Urinary tract infections, Septicaemia, Bone and joint infections, Gynaecological infections
Adult Dose
Intravenous
Meningitis, Respiratory tract infections, Skin and soft tissue infections, Intra-abdominal infections, Urinary tract infections, Septicaemia, Bone and joint infections, Gynaecological infections
Adult: Ratio of sulbactam:cefoperazone is 1:1. Doses are expressed in terms of cefoperazone. Mild to moderate infections: 1-2 g daily, given in equally divided doses every 12 hr. Severe infections: Up to 4 g daily, given in equally divided doses every 12 hr; max dose of sulbactam: 4 g daily.
Child Dose
Intravenous
Meningitis, Respiratory tract infections, Skin and soft tissue infections, Intra-abdominal infections, Urinary tract infections, Septicaemia, Bone and joint infections, Gynaecological infections
Child: Ratio of sulbactam:cefoperaone is 1:1. Doses are expressed in terms of cefoperazone. Recommended doses: 20-40 mg/kg/day, given in equally divided doses every 6-12 hr. For serious infections: Up to 160 mg/kg/day, given in 2-4 equally divided doses may be used. Max dose of sulbactam: 80 mg/kg/day
Renal Dose
Renal impairment: Dose adjustments may be needed.
Administration
Contra Indications
Hypersensitivity. Known allergy to penicillins.
Precautions
Pregnancy, lactation.
Pregnancy-Lactation
Interactions
With aminoglycosides: Concomitant admin may increase risk of nephrotoxicity. With heparin/warfarin: Concurrent use may cause marked hypoprothrombinemia and/or prolonged bleeding time.
Adverse Effects
Side effects of Cefoperazone + Sulbactam :
Rash, skin reactions, fever, eosinophilia, urticaria, and pruritus. Haematological - Slight decreases in Hb conc and haematocrit value. GI effects, diarrhoea or loose stools, nausea, and vomiting. Mild, transient elevations of serum SGOT, SGPT, and alkaline phosphatase concentrations. Renal effects - Transient elevations in BUN and serum creatinine concentrations.
Mechanism of Action
Cefoperazone, a bactericidal antibiotic, inhibits bacterial cell wall synthesis of actively dividing cells by binding to one or more penicillin binding proteins (PBPs). Sulbactam is a beta-lactamase inhibitor and acts primarily by irreversible inactivation of beta-lactamases.
Note
Magtam 1gm +1gm Injection manufactured by Alkem Laboratories Ltd.. Its generic name is Cefoperazone + Sulbactam. Magtam is availble in Nepal.
Farmaco Nepal drug index information on Magtam Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.