Malirid 7.5 Tablet
Primaquine
7.5mg
Ipca Laboratories Ltd.
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 3.56 NPR |
Indications
Malirid 7.5 Tablet is used for:
Malaria
Adult Dose
Oral
Prevention of relapse of P. vivax malaria
30 mg PO qDay for 14 days
Uncomplicated P. vivax and P. ovale malaria
30 mg PO qDay for 14 days with chloroquine or hydroxychloroquine
Alternatively, for mild G6PD deficiency or as alternative to daily regimen: 45 mg PO qDay for 8 weeks (only to be used after consultation with an infectious disease/tropical medicine expert
Chemoprophylaxis
P. vivax and P. ovale maleria: 30 mg PO qDay for 14 days after departure from malaria-endemic area
Child Dose
Oral
Uncomplicated P. vivax and P. ovale malaria
0.5 mg/kg (30 mg/day maximum) qDay for 14 days with chloroquine or hydroxychloroquine
Chemoprophylaxis
0.5 mg/kg PO qDay (30 mg/day maximum); start 1-2 days prior to travel and continue for 7 days after departure from malaria endemic area
Renal Dose
Administration
Should be taken with food. Take w/ meals to avoid GI discomfort.
Contra Indications
Hypersensitivity. Childn <1 yr. Acute flare-ups of systemic diseases (RA, SLE) having tendency for agranulocytopaenia, Pregnancy and lactation.
Precautions
G6PD deficiency; pregnancy; NADH methaemoglobin reductase deficient patients. Monitor Hb levels and blood counts routinely. Patients with systemic diseases that have an increased risk of granulocytopenia. Withdraw treatment if signs of haemolysis or methaemogloinaemia occur.
Pregnancy-Lactation
Interactions
Primaquine may inhibit metabolism of chloroquine. Avoid ethanol.
Potentially Fatal: Mepacrine may potentiate toxicity of primaquine. Potentially haemolytic drugs eg, sulphonamides, nitrofurans and bone marrow suppressants eg, methotrexate, phenylbutazone, chloramphenicol should not be co-admin with primaquine.
Adverse Effects
Side effects of Primaquine :
>10%
Abdominal pain,Hemolytic anemia in G6PD deficiency,Nausea,Vomiting
<1-10%
Methemoglobinemia in NADH-methemoglobin reductase-deficient individuals
<1%
Agranulocytosis,Arrhythmias,Headache,Interference with visual accommodation,Leukopenia,Leukocytosis,Rash,Dizziness,Pruritus
Potentially Fatal: Haemolytic anaemia (G6PD deficient), thrombocytopaenia, leucopaenia, AV block.
Mechanism of Action
Primaquine is an 8-aminoquinoline antimalarial which eliminates the exoerythrocytic forms of malarial parasite P.vivax, P. falciparum by disrupting mitochondria and binding to DNA. By this action primaquine achieves radical cure of vivax malaria. It is also active against gametocytes of P.falciparum.
Note
Malirid 7.5 7.5mg Tablet manufactured by Ipca Laboratories Ltd.. Its generic name is Primaquine. Malirid 7.5 is availble in Nepal.
Farmaco Nepal drug index information on Malirid 7.5 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.