Mannitol Injection
Mannitol 20%
100ml
Tablets India Limited.
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| Retail Price | 104.00 NPR |
Indications
Mannitol Injection is used for:
Chronic bronchitis, Cerebral oedema, Oliguric phase of renal failure, Raised intracranial pressure, Renal function testing, Transurethral prostatic resection
Adult Dose
Intravenous
Oliguric phase of renal failure
Adult: 50-100 g in a 24-hr period by IV infusion. Adjust rate of administration to maintain a urine flow of at least 30-50 mL/hr.
Cerebral oedema, Reduction of raised intraocular pressure
Adult: 0.25-2 g/kg by IV infusion given over 30-60 minutes.
Renal function testing
Adult: 0.2 g/kg infused over 3-5 min.
Child Dose
Intravenous
Edema
0.25-1 g/kg IV initially; maintenance dose of 0.25-0.5 g/kg IV q4-6hr
Anuria/Oliguria
Test dose: 0.2 g/kg IV over 3-5 minutes; not to exceed 12.5 g
Discontinue if no diuresis within 2 hr
Renal Dose
Administration
Contra Indications
Pulmonary congestion or oedema; intracranial bleeding; CHF; metabolic oedema with abnormal capillary fragility; anuria due to severe renal disease; severe dehydration.
Precautions
Hypervolaemia; urinary tract obstruction; check for signs of fluid and electrolyte imbalance. Should not be administered with whole blood. Pregnancy, lactation.
Pregnancy-Lactation
Interactions
Increased nephrotoxicity with ciclosporin.
Adverse Effects
Side effects of Mannitol 20% :
Fluid and electrolyte imbalance; acidosis (with high doses). Nausea, vomiting, thirst; headache, dizziness, convulsions, chills, fever; tachycardia, chest pain; blurred vision; urticaria and hypotension or hypertension; acute renal failure; skin necrosis; thrombophloebitis.
Mechanism of Action
Mannitol increases urinary output by inhibiting tubular reabsorption of water and electrolytes. It raises the osmotic pressure of the plasma allowing water to be drawn out of body tissues.
Note
Mannitol 100ml Injection manufactured by Tablets India Limited.. Its generic name is Mannitol 20%. Mannitol is availble in Nepal.
Farmaco Nepal drug index information on Mannitol Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.