Martifur Tablet
Nitrofurantoin
100mg
Walter Bushnell
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| Retail Price | 7.69 NPR |
Indications
Martifur Tablet is used for:
Uncomplicated UTI, Urinary Tract Infection
Adult Dose
Oral
Acute uncomplicated urinary tract infections
Adult: 50-100 mg 4 times daily for 7 days or for 3 days after obtaining sterile urine.
SR preparation: 100 mg bid for 7 days or for 3 days after obtaining sterile urine.
Prophylaxis of uncomplicated urinary tract infections
Adult: 50-100 mg at bedtime for up to 12 months.
Child Dose
Urinary Tract Infection
>1 month
5-7 mg/kg/day PO divided q6hr for 7 days
UTI prophylaxis: 1-2 mg/kg PO qHS or 2 divided doses
>12 years
50-100 mg PO q6hr for 7 days or for 3 days after obtaining sterile urine
SR preparation: 100 mg PO q12hr for 7 days or for 3 days after obtaining sterile urine
Long-term prophylaxis/suppression: 50-100 mg PO at bedtime for up to 12 months
Renal Dose
Loses effectiveness in patients with CrCl <60 mL/min due to inadequate urine concentration
Monitor renal function; renally excreted; decreased renal function more likely in elderly
Administration
Should be taken with food. Take w/ or immediately after meals. Sustained release macrocrystals indicated only for patients >12 years for acute UTIs (cystitis) caused by E coli or S saprophyticus
Contra Indications
Severe renal impairment (anuria, oliguria, significantly elevated serum creatinine, CrCl <60 ml/min). Hypersensitivity to nitrofurans, G6PD deficiency, infants <3 mth. Pregnancy at term, during labour and delivery, or when the onset of labour is imminent.
Precautions
Elderly. Monitor hepatic and pulmonary function during prolonged therapy. Pre-existing pulmonary, hepatic, neurological, or allergic disorders, predisposition to peripheral neuropathy e.g. renal impairment, anaemia, DM, electrolyte imbalance, debility, vitamin B deficiency. Withdraw if signs of peripheral neuropathy occur. Lactation.
Lactation: Enters breast milk; discontinue drug or do not nurse
Pregnancy-Lactation
Interactions
Reduced excretion with probenecid or sulfinpyrazone. Absorption reduced by magnesium trisilicate. Antagonistic effects with quinolone antibacterials. Reduced effects with carbonic anhydrase inhibitors or urinary alkalinisers.
Adverse Effects
Side effects of Nitrofurantoin :
Nausea, vomiting, anorexia, abdominal pain, diarrhoea; headache, drowsiness, vertigo, dizziness, nystagmus, benign intracranial hypertension; rash, urticaria, pruritus, fever, sialadenitis, angioedema, erythema multiforme, exfoliative dermatitis, pancreatitis, lupus-like syndrome, myalgia, arthralgia; acute pulmonary sensitivity reactions; megaloblastic anaemia, leucopenia, granulocytopenia or agranulocytosis, thrombocytopenia, aplastic anaemia, haemolytic anaemia (in G6PD-deficient patients); transient alopecia; brownish discolouration of urine.
Potentially Fatal: Peripheral polyneuropathy, hepatotoxicity, anaphylaxis, Stevens-Johnson syndrome, interstitial pneumonitis, pulmonary fibrosis.
Mechanism of Action
Nitrofurantoin interferes with cell metabolism and cell wall synthesis by inhibiting several enzyme systems including acetyl coenzyme A. It is bactericidal to most gram-positive and gram-negative urinary tract pathogens.
Note
Martifur 100mg Tablet manufactured by Walter Bushnell. Its generic name is Nitrofurantoin. Martifur is availble in Nepal.
Farmaco Nepal drug index information on Martifur Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.