Matergam P Injection
Human Anti-D Immunoglobulin
300mg
Zydus Pharmaceuticals
| Pack size | 1ml |
|---|---|
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Indications
Matergam P Injection is used for:
Hemolytic disease of newborn, Rhesus disease
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Patients who have had an anaphylactic or severe systemic reaction to the administration of human immune globulin. IgA-deficient patients with antibodies to IgA and a history of hypersensitivity.
Precautions
IgA deficient patients with known antibodies to IgA are at greater risk of developing severe hypersensitivity and anaphylactic reactions .
It is made from human blood; therefore it may contain infectious agents; e.g., viruses and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent
Pregnancy-Lactation
Interactions
May interfere with the immune response to live measles vaccine, live mumps vaccine, live rubella vaccine and live varicella vaccine, therefore these vaccines should be given at least 3 wk before or 3 mth after the admin of the immunoglobulins.
Adverse Effects
Side effects of Human Anti-D Immunoglobulin :
The most serious adverse reactions in patients receiving Rh0(D) Immune Globulin Intravenous (Human) have been observed in the treatment of ITP and include intravascular hemolysis, clinically compromising anemia, acute renal insufficiency, and, very rarely, DIC and death
The most common adverse reactions observed in the use for suppression of Rh isoimmunization (?0.5% of subjects) are nausea, dizziness, headache, injection-site pain, and malaise.
The most common adverse reactions observed in the treatment of ITP (>14% of subjects) are chills, pyrexia/increased body temperature, and headache. Mild hemolysis (manifested by an increase in bilirubin, a decrease in hemoglobin, or a decrease in haptoglobin) was also observed.
Mechanism of Action
Anti-Rho(D) immune globulins from human donors.
Note
Matergam P 300mg Injection manufactured by Zydus Pharmaceuticals. Its generic name is Human Anti-D Immunoglobulin. Matergam P is availble in Nepal.
Farmaco Nepal drug index information on Matergam P Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.