Mefpas Tablet
Mefenamic Acid
500mg
QMED Pharma
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 5.00 NPR |
Indications
Mefpas Tablet is used for:
Rheumatoid arthritis, Osteoarthritis, Dysmenorrhoea, Menorrhagia, Dental pain, Pain and inflammation, Mild to moderate pain, Postoperative pain
Adult Dose
Oral
Rheumatoid arthritis; Mild to moderate pain; Dental pain; Postoperative pain; Dysmenorrhoea; Osteoarthritis; Menorrhagia
Adult: 250-500 mg upto 3 times daily for 3-7 days. Max. 1.5 gm total.
Child Dose
Oral
Rheumatoid arthritis; Mild to moderate pain; Dental pain; Postoperative pain; Dysmenorrhoea; Osteoarthritis; Menorrhagia
Child: >6 mth 25 mg/kg daily in divided doses for up to 7 days.
Renal Dose
Administration
Should be taken with food.
Contra Indications
Hypersensitivity to mefenamic acid, aspirin or other NSAIDs. Patient w/ inflammatory bowel disease, active ulceration or chronic inflammation of the upper or lower GI tract, renal failure. History of asthma, urticaria, allergic-type reactions. Treatment of perioperative pain in the setting of CABG surgery, pregnancy (3rd trimester), lactation. Coronary artery bypass graft surgery, severe renal impairment, severe heart failure.
Precautions
Patient w/ known CV disease or risk factors for CV disease, history of GI bleeding or peptic ulceration, fluid retention or heart failure. Renal and hepatic impairment. Anemia, bronchospasm, HTN, SLE, fluid retention, bleeding diathesis. Pregnancy and lactation.
Patient Counselling May impair ability to drive or operate machinery. Monitoring Parameters Monitor CBC, chemistry profile, hepatic and renal function during long-term therapy. BP should be monitored closely during initiation and throughout therapy.
Lactation: contraindicated; excreted in breast milk
Pregnancy-Lactation
Pregnancy Category: C; D in 3rd trimester or near delivery.
Interactions
Concomitant use w/ CYP2C9 isoenzyme inhibitors may alter safety and efficacy of mefenamic acid. May enhance methotrexate toxicity. Reduced BP response to ACE inhibitors or angiotensin II receptor antagonists. Increased risk of serious GI events w/ aspirin. May reduce the natriuretic effects of furosemide or thiazide diuretics. Reduced renal lithium clearance and elevated plasma lithium levels. May enhance anticoagulant effect of warfarin.
Adverse Effects
Side effects of Mefenamic Acid :
>10%
Borderline elevations of one or more LFTs (<15%)
1-10%
Abdominal pain,Anorexia,Diarrhea,Nausea,Pyrosis,Gastritis,Flatulence,Constipation,Steatorrhea,Upper GI ulcers, gross bleeding/perforation (1% of patients treated for 3-6 mth and 2-4% of those treated for 1 yo)
<1%
Leukopenia,Eosinophilia,Thrombocytopenic purpura,Agranulocytosis,Pancytopenia,Bone marrow hypoplasia,Renal failure (including papillary necrosis & acute interstitial nephritis),Acute interstitial nephritis has been associated with hematuria, proteinuria, & nephrotic syndrome
Potentially Fatal: Autoimmune haemolytic anaemia; convulsions (overdosage).
Mechanism of Action
Mefenamic acid, an anthranilic acid derivative, is a prototypical NSAID. It reversibly inhibits the cyclooxygenase-1 and -2 (COX-1 and -2) enzymes, thus resulting in reduced synthesis of prostaglandin precursors. It has analgesic and antipyretic properties w/ minor anti-inflammatory activity.
Note
Mefpas 500mg Tablet manufactured by QMED Pharma. Its generic name is Mefenamic Acid. Mefpas is availble in Nepal.
Farmaco Nepal drug index information on Mefpas Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.