Melaclean Cream
Hydroquinone + Fluticasone + Tretinoin Topical
Maruti Pharma Pvt. Ltd.
| Pack size | 15g |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 225.00 NPR |
Indications
Melaclean Cream is used for:
Melasma
Adult Dose
Topical/Cutaneous
Moderate to severe melasma of the face
Adult: Apply a thin layer onto the hyperpigmented areas of melasma once daily, 30 minutes before bedtime. Treatment duration should not exceed 8 wk.
Child Dose
Renal Dose
Administration
Wash face gently before application; rinse & pat dry
Apply thin film to hyperpigmented area & 1/2 inch surrounding skin
Do not use occlusive dressing
Contra Indications
A history of hypersensitivity, allergy, or intolerance to this product or any of its components.
Precautions
Cream contains hydroquinone and tretinoin that may cause mild to moderate irritation such as skin reddening, peeling, mild burning sensation, dryness, and pruritus. Transient skin reddening or mild burning sensation does not preclude treatment. If a reaction suggests hypersensitivity or chemical irritation, the use of the medication should be discontinued.
Cream also contains the corticosteroid. Systemic absorption of topical corticosteroids can produce reversible hypothalamic-pituitary-adrenal (HPA) axis suppression with the potential for glucocorticosteroid insufficiency after withdrawal of treatment. Manifestations of Cushing’s syndrome, hyperglycemia, and glucosuria can also be produced by systemic absorption of topical corticosteroid while on treatment. If HPA axis suppression is noted, Cream should be discontinued.
Lactation: not known whether excreted in breast milk; use caution
Pregnancy-Lactation
Interactions
Medicated or abrasive soaps & cleansers, soaps & cosmetics w/ drying effects, products w/ high conc of alcohol & astringent, & other irritants or keratolytic drugs. Medications w/ photosensitizing effects.
Adverse Effects
Side effects of Hydroquinone + Fluticasone + Tretinoin Topical :
>10%
Erythema (41-45%),Desquamation (36-40%),Burning (16-20%),Dryness (11-15%),Pruritis (11-15%)
1-10%
Acne (5%)
Mechanism of Action
Fluticasone utilises a fluorocarbothioate ester linkage at the 17 carbon position. It has potent vasoconstrictive and anti-inflammatory activity, but weak hypothalamic-pituitary-adrenal (HPA) inhibitory effect when applied topically. Hydroquinone is used as a depigmenting agent. Tretinoin is a retinoid that is appears to stimulate mitosis, increases turnover of follicular epithelial cells and reduces their cohesiveness.
Note
Melaclean Cream manufactured by Maruti Pharma Pvt. Ltd.. Its generic name is Hydroquinone + Fluticasone + Tretinoin Topical. Melaclean is availble in Nepal.
Farmaco Nepal drug index information on Melaclean Cream is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.