Melanocyl Solution
Methoxsalen
1% w/v
Franco-Indian Pharmaceuticals Pvt. Ltd.
| Pack size | 25ml |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 75.71 NPR |
Available as:
Indications
Melanocyl Solution is used for:
Psoriasis, Vitiligo, Eczema, T-Cell Lymphoma
Adult Dose
Topical
Vitiligo:
Adults and children 12 years of age and over
Apply to the affected area of the skin 2 hr before UV exposure q3-7 days.
The amount and time of UVA light for each treatment is based on skin type and response to treatment. patient may have UVA light treatments 2 to 4 times a week when first start and then less frequently as condition improves.
Child Dose
Topical
Vitiligo:
Children 12 years of age and over
Apply to the affected area of the skin 2 hr before UV exposure q3-7 days.
<12 years old: safety and efficacy not established
Renal Dose
Administration
Apply over lesions then expose to UVA immediately after application or wait up to 2 hr. Protect the area surrounding the lesion w/ a sunscreen. Wash and protect lesions from light after treatment; protection may be up to >48 hr. Treatment is usually repeated once wkly. Substantial repigmentation usually requires 6-9 mth of treatment.
Contra Indications
Hypersensitivity. Aphakia, existing or history of melanoma, invasive squamous cell carcinoma, photosensitivity diseases (e.g. porphyria, acute lupus erythematosus, xeroderma pigmentosum).
Precautions
Patient exhibiting multiple basal cell carcinoma or history of basal cell carcinoma, previous arsenic therapy, previous x-ray or grenz ray therapy; cardiac diseases or those unable to tolerate prolonged standing or exposure to heat stress; GI diseases or chronic infection. Hepatic impairment. Pregnancy and lactation.
Lactation: not known whether excreted in breast milk; use caution
Pregnancy-Lactation
Interactions
Additive effects with drugs known to cause photosensitisation e.g. anthralin, coal tar or derivatives, griseofulvin, phenothiazines, nalidixic acid, sulfonamides., tetracyclines and thiazide diuretics. May increase the levels/effects of aminophylline, fluvoxamine, mexiletine, mirtazapine, ropinirole, theophylline, trifluoperazine, dexmedetomidine and ifosfamide.
Adverse Effects
Side effects of Methoxsalen :
All Patients
Mild-moderate erythema x 24-48 hrs
1-10%
Nausea,Pruritis
Frequency Not Defined
Edema,Dizziness,Headache,Malaise,Depression,Hypopigmentation,Bullae formation,Rash,Herpes simplex,Uritcaria,GI disturbances,Leg cramps,Hypotension,Extension of psoriasis
Mechanism of Action
Methoxsalen increases skin reactivity to long-wavelength UV rays. It bonds covalently to DNA inhibiting DNA synthesis and cell division, which can lead to cell injury. This effect is used in photochemotherapy or PUVA and high-intensity long-wavelength UVA irradiation].
Note
Melanocyl 1% w/v Solution manufactured by Franco-Indian Pharmaceuticals Pvt. Ltd.. Its generic name is Methoxsalen. Melanocyl is availble in Nepal.
Farmaco Nepal drug index information on Melanocyl Solution is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.