Meronem Injection
Meropenem
500mg
Astra Zeneca
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| Retail Price | 2244.66 NPR |
Available as:
Indications
Meronem Injection is used for:
Cystic fibrosis, Intra-abdominal infections, Meningitis, Skin and skin structure infections, Diabetic foot infection
Adult Dose
Intravenous
Intra-abdominal infections
Adult: 1 g 8 hrly via IV inj over approx 3-5 min or infused over approx 15-30 min.
Skin and skin structure infections
Adult: 500 mg 8 hrly via IV inj over approx 3-5 min or infused over approx 15-30 min.
Cystic fibrosis, Meningitis
Adult: 2 g 8 hrly infused over approx 15-30 min.
Susceptible infections
Adult: 0.5-1 g 8 hrly via IV inj over approx 3-5 min or infused over approx 15-30 min.
Hepatic impairment: No dosage adjustment needed.
Child Dose
Children:
IV 60 mg/kg/day, max 3 g/day q8h
120 mg/kg/day meningitis, max 6 g/day q8h
Intravenous
Intra-abdominal infections
Child: >3mth ?50 kg: 20 mg/kg 8 hrly via IV inj over approx 3-5 min or infused over approx 15-30 min. Max: 1000 mg.
Skin and skin structure infections
Child: >3 mth ?50 kg: 10 mg/kg 8 hrly via IV inj over approx 3-5 min or infused over approx 15-30 min. Max: 500 mg.
Cystic fibrosis, Meningitis
Child: >3 mth ?50 kg: 40 mg/kg 8 hrly via IV inj over approx 3-5 min or infused over approx 15-30 min. Max: 2 g.
Susceptible infections
Child: >3 mth ?50 kg: 10 or 20 mg/kg 8 hrly via IV inj over approx 3-5 min or infused over approx 15-30 min.
Renal Dose
Renal impairment:
CrCl (ml/min)
26-50 Usual dose 12 hrly.
10-25 Half the usual dose 12 hrly.
<10 Half the usual dose 24 hrly.
Administration
IV Administration
Administer IV infusion over 15-30 minutes; administer IV bolus over 3-5 minutes
Contra Indications
Hypersensitivity to meropenem, other carbapenems. History of anaphylactic reaction to β-lactams (e.g. penicillins, cephalosporins).
Precautions
Patient w/ underlying CNS disorders (e.g. brain lesions, history of seizures. Not recommended for treatment of MRSA. Renal impairment. Childn. Pregnancy and lactation. Monitoring Parameters Monitor for signs of anaphylaxis during 1st dose. Periodically assess renal, hepatic, and haematopoietic functions during prolonged therapy.
Lactation: Unknown whether drug is excreted in breast milk; use with caution
Pregnancy-Lactation
Interactions
Increased plasma concentration w/ probenecid. May decrease plasma levels of valproic acid thus, increasing the risk of seizures.
Adverse Effects
Side effects of Meropenem :
1-10%
Constipation (1-7%),Diarrhea (4-5%),Nausea or vomiting (1-4%),Rash (2-3%; includes diaper-area moniliasis in pediatric patients),Headache (2%),Inflammation at injection site (2%),Sepsis (2%),Oral moniliasis (≤2% in pediatric patients),Bleeding (1.2%),Apnea (1%),Constipation (1%),Glossitis (1%),Injection-site reaction (1%),Phlebitis or thrombophlebitis (1%),Pruritus (1%),Septic shock (1%)
<1%
Agranulocytosis,Angioedema,Erythema multiforme,Hypersensitivity reaction,Hypokalemia,Leukopenia,Neutropenia,Pleural effusion,Stevens-Johnson syndrome,Toxic epidermal necrolysis disorders or renal impairment.
Potentially Fatal: Anaphylaxis; pseudomembranous colitis; Stevens-Johnsons sydrome.
Mechanism of Action
Meropenem is a synthetic carbapenem beta-lactam antibiotic that exerts its bactericidal activity by inhibiting bacterial cell wall synthesis in gm+ve and gm-ve bacteria through binding to several penicillin-binding proteins (PBPs).
Note
Meronem 500mg Injection manufactured by Astra Zeneca. Its generic name is Meropenem. Meronem is availble in Nepal.
Farmaco Nepal drug index information on Meronem Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.