Mesaze OD Tablet
5 Aminosalicylic Acid (Mesalamine)
40mg
Asian Pharmaceuticals Pvt. Ltd.
| Pack size | 100's |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 40.00 NPR |
Available as:
Indications
Mesaze OD Tablet is used for:
Ulcerative colitis, Ulcerative proctitis, Crohn's Disease.
Adult Dose
For the treatment of mildly to moderately active ulcerative colitis: The usual dosage in adults is two 400 mg tablets to be taken three times a day for a total daily dose of 2.4 grams for a duration of 6 weeks.
For the maintenance of remission of ulcerative colitis: The recommended dosage in adults is 1.6 grams daily, in divided doses. Treatment duration in the prospective, well-controlled trial was 6 months.
Crohn`s disease: 800 mg 3 times daily.
Hepatic impairment: Avoid in severe impairment.
Child Dose
Ulcerative colitis: Dose is dependant on preparation and brand used. Tablets: 5-15 yr: Acute attack: 15-20 mg/kg (max: 1 g) tid; maintenance of remission: 10 mg/kg (max: 500 mg) 2-3 times daily.
Renal Dose
Renal impairment:
CrCl (ml/min)
<20 Avoid.
Administration
May take with or without food.
Contra Indications
Hypersensitivity to salicylates, aminosalicylates, or any component of the product.- Severe renal impairment (GFR less than 30 mL per minute).- Severe liver impairment.- Gastric and duodenal ulcers- Children under the age of 2 years
Precautions
Mild to moderate impaired renal or hepatic function (test serum creatinine before treatment, every 3 mth for 1st yr, every 6 mth for next 4 yr, then annually). Elderly; active peptic ulcer; pregnancy, lactation; patients predisposed to pericarditis or myocariditis. Counsel patients to report any unexplained bleeding, bruising, purpura, sore throat, fever or malaise during treatment; perform blood count and stop treatment if blood dyscrasias suspected.
Counsel patients taking delayed release tablets to report repeatedly unbroken or partially broken tablets in their faeces. Pyloric stenosis may delay release into colon.Patients with pulmonary disease, in particular asthma, should be very carefully monitored during a course of treatment.Hypersensitivity to Sulphasalazine.In patients with a history of hypersensitivity to sulphasalazine, therapy should be initiated only under close medical supervision.
Treatment must be stopped immediately if acute symptoms of intolerance occur such as abdominal cramps, acute abdominal pain, fever, severe headache and rash.Paediatric populationThere is only limited documentation for an effect in children (age 6-18 years).
Lactation: Not known whether drug or metabolites are distributed into breast milk; use caution.
Pregnancy-Lactation
Interactions
Do not give with lactulose or other drugs which lower pH for they prevent release of mesalazine. May decrease digoxin absorption.
Adverse Effects
Side effects of 5 Aminosalicylic Acid (Mesalamine) :
Abdominal pain (4-8%), GI discomfort (4-8%),Headache (7%),Flatulence (1-6%),Nausea (1-6%),Fatigue (3%),Asthenia (3%),Malaise (3%),Weakness (3%),Fever (3%),Exacerbation of colitis (3%),Dizziness (2-3%),Rash (1-3%),Pruritus (1-3%),Acne (1-3%)
Frequency Not Defined
Pericarditis (rare),Pharyngitis,Sensitivity reaction,Cholestatic hepatitis,Creatinine clearance decreased,Flu like syndrome,Discolored urine
Potentially Fatal: Blood dyscrasias, aplastic anaemia, agranulocytosis; renal toxicity.
Mechanism of Action
Anti-inflammatory agent; mesalamine (5-aminosalicylic acid) is the active component of sulfasalazine, but specific MOA is unknown; probably inhibits prostaglandin and leukotriene synthesis and release in colon. Action may be topical in terminal ileum and colon rather than systemic.
Note
Mesaze OD 40mg Tablet manufactured by Asian Pharmaceuticals Pvt. Ltd.. Its generic name is 5 Aminosalicylic Acid (Mesalamine). Mesaze OD is availble in Nepal.
Farmaco Nepal drug index information on Mesaze OD Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.