Mesna Injection
Mesna Disulfide
100mg
DABUR INDIA LTD.
| Pack size | 1's |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 47.60 NPR |
Indications
Mesna Injection is used for:
Urothelial toxicity
Adult Dose
Intravenous
Prophylaxis against urothelial toxicity
With Ifosfamide
240 mg/sq.meter (if receiving 1.2 g/sq.meter ifosfamide dose) IVP 15 minutes before & 4 & 8 hours after ifosfamide admin OR
240 mg/sq.meter (if receiving 1.2 g/sq.meter ifosfamide dose) IVP 15 minutes before & 480 mg/sq.meter PO 2 & 6 hours after ifosfamide admin
Adjust dose accordingly if ifosfamide dose changes
Also given by alternative IVP regimens, intermittent infusion or continuous infusion-
Child Dose
Renal Dose
Administration
IV Preparation
Reconstitute w/ D5W, NS, dextrose/saline or LR to a final concentration of 20 mg/mL
IV Administration
IVP: bolus 15 min before ifosfamide
Intermittent infusion over 15-30 min
Continuous Infusion: may be added to ifosfamide/cyclophosphamide in infusion bag
Additive compatibility w/ cyclophosphamide shown only in D5W & LR
Contra Indications
Hypersensitivity to thiol-containing compounds.
Precautions
Protective effect applies only to the urinary tract; pregnancy, lactation. Patients with auto-immune disorders. IV formulation may contain benzyl alcohol as a preservative; avoid in neonates or infants. Instruct patients to seek medical attention if discolouration of urine occurs. During treatment, monitor urine for erythrocytes and haematuria. Maintain adequate hydration in all patients. Patients who vomit within 2 hr of oral dose should repeat dose or receive IV dose.
Lactation: not known if excreted in breast milk, do not nurse
Pregnancy-Lactation
Interactions
Mesna is incompatible in vitro with cisplatin and nitrogen mustard.
Adverse Effects
Side effects of Mesna Disulfide :
>10%
Nausea (>50%),Vomiting (29%),Anorexia.Asthenia,Fatigue,Fever,Abdominal pain,Constipation,Anemia,Granulocytopenia,Leukopenia,Thrombocytopenia,Alopecia
1-10%
Anxiety,Confusion,Dizziness,Headache,Insomnia,Pain,Somnolence,Chest pain,Edema,Flushing,Tachycardia,Cough,Dyspnea,Pneumonia,Diarrhea,Hematuria,Hypokalemia,Back pain,Dehydration,Injection site reaction,Pallor
Potentially Fatal: May cause haemorrhagic cystitis, systemic anaphylactic reactions.
Mechanism of Action
Mesna is used to prevent urothelial toxicity associated with oxazaphosphorine, ifosfamide or cyclophosphamide. It acts in the kidney; reacting with thiol groups of urotoxic metabolites (e.g. acrolein) of ifosfamide and cyclophosphamide. It is used as a mucolytic in the management of some respiratory tract conditions e.g. cystic fibrosis where other mucolytics have failed. It acts by reducing the viscosity of pulmonary secretions; the drug's free sulfhydryl group is thought to reduce disulfide linkages of mucoproteins.
Note
Mesna 100mg Injection manufactured by DABUR INDIA LTD.. Its generic name is Mesna Disulfide. Mesna is availble in Nepal.
Farmaco Nepal drug index information on Mesna Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.