Metdil Suspension

Metronidazole + Diloxanide Furoate

400mg + 500 mg

Time Pharmaceuticals Pvt. Ltd.

Pack size	50ml
Dispensing mode
Source
Agent
Retail Price	36.01 NPR

Indications

Metdil Suspension is used for: Treatment of amoebiasis and other protozoal disease.

Adult Dose

Oral 1 (400/500mg) Tablet 3 times daily for 7-10 days. Susp: (200/250 mg/5ml): 2 tsf 3 times daily.

Child Dose

Oral Child Susp: (200/250 mg/5ml): 1-2 tsf 3 times daily.

Renal Dose

Administration

Contra Indications

Hypersensitivity, blood dyscrasias, active CNS disease, serious neurological disease, seizures, severe hepatic failure, 1st trimester pregnancy, lactation.

Precautions

Severe Renal & Hepatic impairment. Caution should be exercised in pregnant and breastfeeding women.

Pregnancy-Lactation

Interactions

Acute psychoses with disulfiram. Additive or synergistic effect with other antimicrobials. Disulfiram like reaction with alcohol. Enhances action of coumarin anticoagulants. Blood levels increased by cimetidine. Effect reduced by phenobarbitone.

Adverse Effects

Side effects of Metronidazole + Diloxanide Furoate : Seizures, headache, dizziness, peripheral neuropathies, unpleasant metallic taste, furred tongue, glossitis, pseudomembranous colitis, GI disturbances, rash, urticaria, pruritus, paraesthesias, superinfection; transient leucopaenia, thrombocytopenia. Raised liver enzyme values, cholestatic hepatitis, jaundice.

Mechanism of Action

Metronidazole is converted to reduction products that interact w/ DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms. It is active against most anaerobic protozoa, some gm+ve, gm-ve and facultative anaerobes. Diloxanide is a luminal amoebicide which is hydrolysed in the gut, thus releasing the free diloxanide which acts as an amoebicide. It is given alone in asymptomatic cyst passers. For patients with active amoebic infections, it can be administered with a 5-nitroimidazole e.g. metronidazole or tinidazole.

Note

Metdil 400mg + 500 mg Suspension manufactured by Time Pharmaceuticals Pvt. Ltd.. Its generic name is Metronidazole + Diloxanide Furoate. Metdil is availble in Nepal. Farmaco Nepal drug index information on Metdil Suspension is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Metronidazole + Diloxanide Furoate :

Tablet

Diarstat forte ^{400mg + 500mg}

Nepal Pharmaceuticals Pvt. Ltd.

Tablet

Protogyl DF ^{400mg + 500mg}

Deurali Janta Pharmaceuticals Pvt. Ltd.

Suspention

Protogyl DF ^{100mg + 125mg/5ml}

Deurali Janta Pharmaceuticals Pvt. Ltd.

Suspention

Diarstat

Nepal Pharmaceuticals Pvt. Ltd.

Tablet

Amet DF forte ^{400mg + 500mg}

Apex Pharmaceuticals Pvt. Ltd.