Methimex 10 Tablet

Methimazole
10mg
Sun Pharmaceutical Industries Ltd.
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Indications

Methimex 10 Tablet is used for: Hyperthyroidism, Graves Disease

Adult Dose

Hyperthyroidism Mild: 15 mg/day PO divided q8hr initially Moderate: 30-40 mg/day PO divided q8hr initially Severe: 60 mg/day PO divided q8hr initially Maintenance: 5-30 mg/day PO divided q8hr Graves Disease 10-20 mg/day PO once; after euthyroidism is achieved, reduce dosage by 50% and administer for 12-18 months; may subsequently taper or discontinue if TSH levels are normal

Child Dose

Hyperthyroidism Initial: 0.5-0.7 mg/kg/day PO qDay or divided q8hr Maintenance: 0.2 mg/kg/day PO qDay or divided q8hr Not to exceed 30 mg/day Graves Disease 0.2-0.5 mg/kg/day PO; after euthyroidism is achieved, reduce dosage by 50% and administer for 1-2 years

Renal Dose

Administration

Contra Indications

Hypersensitivity, Breastfeeding

Precautions

Lupus-like syndrome reported Hypoprothrombinemia and bleeding may occur; monitor, especially before surgical procedure performed Antineutrophil cytoplasmic autoantibody (ANCA)-positive vasculitis reported; discontinue use in presence of vasculitis Concurrent administration of other agranulocytosis-causing drugs Prolonged treatment may cause hypothyroidism; routinely monitor free T4 levels and TSH; adjust dose as necessary to maintain euthyroid state Significant bone marrow suppression may occur; use caution if administered with other agents known to cause myelosupression; discontinue if significan agranulocytosis, leukopenia, or aplastic anemia occurs Hepatitis reported; discontinue if it occurs or if clinically significant hepatic enzyme levels, including transaminases >3 times upper limit of normal observed Discontinue if unexplained fever occurs Antithyroid agents associated with rare but severe dermatologic reactions; discontinue if exfoliative dermatitis occurs Lactation: Drug distributed in breast milk; use contraindicated by manufacturer (American Academy of Pediatrics [AAP] Committee states that drug is compatible with nursing; American Academy of Family Physicians [AAFP] states that it is safe for nursing)

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Methimazole : Frequency Not Defined Agranulocytosis Alopecia Aplastic anemia Dermatologic reactions (eg, rash, pruritus, skin pigmentation) Hepatotoxicity Leukocytoclastic vasculitis Neuritis Polyarthritis Pruritus Salivary gland swelling Skin pigmentation Thrombocytopenia Urticaria Vertigo

Mechanism of Action

Inhibits synthesis of thyroid hormone by blocking oxidation of iodine in thyroid gland; blocks synthesis of thyroxine (T4) and triiodothyronine (T3)

Note

Methimex 10 10mg Tablet manufactured by Sun Pharmaceutical Industries Ltd.. Its generic name is Methimazole. Methimex 10 is availble in Nepal. Farmaco Nepal drug index information on Methimex 10 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Methimazole :