Methimex 10 Tablet
Methimazole
10mg
Sun Pharmaceutical Industries Ltd.
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Available as:
Indications
Methimex 10 Tablet is used for:
Hyperthyroidism, Graves Disease
Adult Dose
Hyperthyroidism
Mild: 15 mg/day PO divided q8hr initially
Moderate: 30-40 mg/day PO divided q8hr initially
Severe: 60 mg/day PO divided q8hr initially
Maintenance: 5-30 mg/day PO divided q8hr
Graves Disease
10-20 mg/day PO once; after euthyroidism is achieved, reduce dosage by 50% and administer for 12-18 months; may subsequently taper or discontinue if TSH levels are normal
Child Dose
Hyperthyroidism
Initial: 0.5-0.7 mg/kg/day PO qDay or divided q8hr
Maintenance: 0.2 mg/kg/day PO qDay or divided q8hr
Not to exceed 30 mg/day
Graves Disease
0.2-0.5 mg/kg/day PO; after euthyroidism is achieved, reduce dosage by 50% and administer for 1-2 years
Renal Dose
Administration
Contra Indications
Hypersensitivity, Breastfeeding
Precautions
Lupus-like syndrome reported
Hypoprothrombinemia and bleeding may occur; monitor, especially before surgical procedure performed
Antineutrophil cytoplasmic autoantibody (ANCA)-positive vasculitis reported; discontinue use in presence of vasculitis
Concurrent administration of other agranulocytosis-causing drugs
Prolonged treatment may cause hypothyroidism; routinely monitor free T4 levels and TSH; adjust dose as necessary to maintain euthyroid state
Significant bone marrow suppression may occur; use caution if administered with other agents known to cause myelosupression; discontinue if significan agranulocytosis, leukopenia, or aplastic anemia occurs
Hepatitis reported; discontinue if it occurs or if clinically significant hepatic enzyme levels, including transaminases >3 times upper limit of normal observed
Discontinue if unexplained fever occurs
Antithyroid agents associated with rare but severe dermatologic reactions; discontinue if exfoliative dermatitis occurs
Lactation: Drug distributed in breast milk; use contraindicated by manufacturer (American Academy of Pediatrics [AAP] Committee states that drug is compatible with nursing; American Academy of Family Physicians [AAFP] states that it is safe for nursing)
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Methimazole :
Frequency Not Defined
Agranulocytosis
Alopecia
Aplastic anemia
Dermatologic reactions (eg, rash, pruritus, skin pigmentation)
Hepatotoxicity
Leukocytoclastic vasculitis
Neuritis
Polyarthritis
Pruritus
Salivary gland swelling
Skin pigmentation
Thrombocytopenia
Urticaria
Vertigo
Mechanism of Action
Inhibits synthesis of thyroid hormone by blocking oxidation of iodine in thyroid gland; blocks synthesis of thyroxine (T4) and triiodothyronine (T3)
Note
Methimex 10 10mg Tablet manufactured by Sun Pharmaceutical Industries Ltd.. Its generic name is Methimazole. Methimex 10 is availble in Nepal.
Farmaco Nepal drug index information on Methimex 10 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.