Metoz 2.5 Tablet
Metolazone
2.5mg
Centaur Pharmaceuticals Pvt. Ltd.
| Pack size | 10's |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 17.06 NPR |
Available as:
Indications
Metoz 2.5 Tablet is used for:
Oedema, Hypertension
Adult Dose
Oral
Hypertension
Adult: Initially, 1.25 mg daily, adjusted after 3-4 wk according to response. Usual dose: 2.5-5 mg daily, either alone or with other antihypertensives.
Maintenance dose: 5 mg on alternate days.
Formulations with enhanced bioavailability: 0.5-1 mg daily.
Oedema
Adult: 5-10 mg daily, increased if necessary to 20 mg daily. Max: 80 mg in 24 hr.
Elderly: Initially, 2.5 mg/day or every other day.
Child Dose
Oedema
0.2-0.4 mg/kg/day PO in single daily dose or divided q12hr
Renal Dose
Renal impairment: Not necessary to supplement dose in hemodialysis or peritoneal dialysis
Administration
Should be taken with food. Take after breakfast.
Contra Indications
Anuria; hepatic coma or pre-coma. Pregnancy.
Precautions
Pre-diabetes or DM; gout; SLE; hepatic and renal impairment; hypercholesterolaemia. Correct electrolyte disturbances prior to therapy. Risk of cross-sensitivity with sulfonamides, sulfonylureas, carbonic anhydrase inhibitors, thiazides and loop diuretics.
Lactation: Not recommended
Pregnancy-Lactation
Interactions
Hypotensive and nephrotoxic effects of ACE inhibitors may be enhanced. Absorption may be reduced with bile acid sequestrants. Hyperglycaemic effect may be enhanced with diazoxide. May increase serum concentration and QTc-prolonging effect of dofetilide. May reduce lithium excretion. Hypotensive effect may be increased with alcohol.
Potentially Fatal: Increased risk of nephrotoxicity with ciclosporin. Severe electrolyte disturbances may occur with furosemide.
Adverse Effects
Side effects of Metolazone :
Chest pain, palpitation, necrotising angiitis, orthostatic hypotension, syncope, venous thrombosis, vertigo, volume depletion; depression, dizziness, chills, drowsiness, fatigue, restlessness, headache, lightheadedness; petechiae, photosensitivity, hypersensitivity reactions; gout attacks, electrolyte disturbances; abdominal bloating, diarrhoea, abdominal pain, anorexia, constipation, epigastric distress, nausea, xerostomia, pancreatitis, vomiting; impotence; aplastic anaemia, thrombocytopenia, haemoconcentration, leukopenia; cholestatic jaundice, hepatitis; joint pain, muscle cramps, weakness, neuropathy, paraesthesia; blurred vision; increased BUN, glucosuria.
Potentially Fatal: Stevens-Johnson syndrome, toxic epidermal necrolysis.
Mechanism of Action
Metolazone is a thiazide-like diuretic. It inhibits reabsorption of sodium in the distal tubules resulting in increased excretion of sodium and water, as well as potassium and hydrogen ions.
Note
Metoz 2.5 2.5mg Tablet manufactured by Centaur Pharmaceuticals Pvt. Ltd.. Its generic name is Metolazone. Metoz 2.5 is availble in Nepal.
Farmaco Nepal drug index information on Metoz 2.5 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.