Micurazole Gel
Miconazole Nitrate 2% Topical
15gm
Curex Pharmaceuticals Pvt. Ltd.
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Indications
Micurazole Gel is used for:
Skin and nail infections due to dermatophytes, yeasts and other fungi such as: Tinea capitis, corporis, manuum, pedis, barbae, cruris, unguium or onychomycosis. Pityriasis versicolor, candidiasis of skin and nails, stomatitis angularis, otitis externa, mycoses secondarily infected with bacteria.
Adult Dose
Topical/Cutaneous
Adult:
Tinea cruris, corporis & cutaneous canidiasis: Apply to affected area BID for 2 weeks
Tinea versicolor: Apply once daily to affected area for 2 weeks
Tinea pedis: Apply BID to affected area for 4 weeks
Child Dose
Tinea
<2 years: Safety and efficacy not established
>2 years: Apply BID for up to 1 month
Renal Dose
Administration
Contra Indications
History of sensitivity reactions to Miconazole or any of the components of the preparation.
Precautions
For external use only. Avoid introduction into the eyes.
Lactation: not known whether distributed into milk; use caution
Pregnancy-Lactation
Interactions
May increase anticoagulant effect of warfarin. May increase or prolong the effect of the following drugs: Oral hypoglycaemics (e.g. sulfonylureas), phenytoin, HIV protease inhibitors (e.g. saquinavir), antineoplastic agents (e.g. vinca alkaloids, busulfan, docetaxel), Ca channel blockers (e.g. dihydropyridines, verapamil), immunosuppressive agents (e.g. ciclosporin, tacrolimus, sirolimus), carbamazepine, cilostazol, buspirone, disopyramide, alfentanil, sildenafil, alprazolam, brotizolam, midazolam IV, rifabutin, methylprednisolone, trimetrexate, ebastine and reboxetine.
Potentially Fatal: Increased risk of cardiac arrhythmia w/ astemizole, cisapride, dofetilide, halofantrine, mizolastine, pimozide, quinidine, sertindole, terfenadine. May increase exposure to ergot alkaloids leading to ergotism. May increase the risk of rhabdomyolysis w/ HMG-CoA reductase inhibitors (e.g. simvastatin and lovastatin). May increase the effect of triazolam and oral midazolam.
Adverse Effects
Side effects of Miconazole Nitrate 2% Topical :
Irritation,BurningmMaceration,Allergic contact dermatitis
Irritation, burning, maceration, allergic contact dermatitis (all rare)
Mechanism of Action
Miconazole inhibits ergosterol synthesis thus damaging fungal cell wall membrane and increases its permeability, allowing leakage of nutrients.
Note
Micurazole 15gm Gel manufactured by Curex Pharmaceuticals Pvt. Ltd.. Its generic name is Miconazole Nitrate 2% Topical. Micurazole is availble in Nepal.
Farmaco Nepal drug index information on Micurazole Gel is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.