Milrineon 10 Injection

Milrinone
10mg
Neon Laboratories Ltd
Pack size
Dispensing mode
Source
Agent
Retail Price 2103.94 NPR

Indications

Milrineon 10 Injection is used for: Short-term management of severe heart failure, Acutely decompensated heart failure

Adult Dose

Intravenous Short-term management of severe heart failure, Acutely decompensated heart failure Adult: Initially, a loading dose of 50 mcg/kg by slow IV injection over 10 min then continuous maintenance infusion of 0.375-0.75 mcg/kg/min. Adjust according to haemodynamics and clinical response. Max dose 1.13 mcg/kg/day.

Child Dose

Intravenous Short-term management of severe heart failure, Acutely decompensated heart failure Child: Initial loading dose of 75 mcg/kg by IV injection over 10-60 min followed by continuous infusion of 0.5-0.75 mcg/kg/min.

Renal Dose

Renal impairment: CrCl (ml/min) Dosage Recommendation 50 0.43 mcg/kg/min 40 0.38 mcg/kg/min 30 0.33 mcg/kg/min 20 0.28 mcg/kg/min 10 0.23 mcg/kg/min 5 0.20 mcg/kg/min

Administration

IV Preparation Injection: Dilute in NS, 1/2NS, or D5W to 10-20 mL Infusion: Dilute in NS, 1/2NS, or D5W to 200 mcg/mL; use undiluted if giving 20 mg/100 mL in D5W IV Administration Injection: Administer slowly over 10 minutes; may use undiluted for initial direct IV injection Infusion: Administer via calibrated electronic controlled-infusion device

Contra Indications

Heart valve stenosis, acute myocardial infarction.

Precautions

Severe obstructive aortic or pulmonary valvular disease, hypertrophic cardiomyopathy, atrial flutter or fibrillation. Monitor blood pressure, heart rate, ECG, fluid and electrolyte balance. Pregnancy and lactation. Use for >48 hr.

Pregnancy-Lactation

Interactions

Potentially Fatal: Avoid anagrelide due the potential for increased inotropic effects.

Adverse Effects

Side effects of Milrinone : Angina-like chest pain, headache, hypokalaemia, tremor, thrombocytopenia, bronchospasm. Potentially Fatal: Supraventricular and ventricular arrhythmias; hypotension.

Mechanism of Action

Milrinone is a selective phosphodiesterase III inhibitor with positive inotropic and vasodilator activity. It selectively inhibits cyclic adenosine monophosphate (cAMP) phosphodiesterase activity in cardiac and vascular muscles resulting in increased intracellular concentrations of cAMP. It also acts directly on vascular smooth muscle.

Note

Milrineon 10 10mg Injection manufactured by Neon Laboratories Ltd. Its generic name is Milrinone. Milrineon 10 is availble in Nepal. Farmaco Nepal drug index information on Milrineon 10 Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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