Milrineon 10 Injection
Milrinone
10mg
Neon Laboratories Ltd
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| Retail Price | 2103.94 NPR |
Indications
Milrineon 10 Injection is used for:
Short-term management of severe heart failure, Acutely decompensated heart failure
Adult Dose
Intravenous
Short-term management of severe heart failure, Acutely decompensated heart failure
Adult: Initially, a loading dose of 50 mcg/kg by slow IV injection over 10 min then continuous maintenance infusion of 0.375-0.75 mcg/kg/min. Adjust according to haemodynamics and clinical response. Max dose 1.13 mcg/kg/day.
Child Dose
Intravenous
Short-term management of severe heart failure, Acutely decompensated heart failure
Child: Initial loading dose of 75 mcg/kg by IV injection over 10-60 min followed by continuous infusion of 0.5-0.75 mcg/kg/min.
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
50 0.43 mcg/kg/min
40 0.38 mcg/kg/min
30 0.33 mcg/kg/min
20 0.28 mcg/kg/min
10 0.23 mcg/kg/min
5 0.20 mcg/kg/min
Administration
IV Preparation
Injection: Dilute in NS, 1/2NS, or D5W to 10-20 mL
Infusion: Dilute in NS, 1/2NS, or D5W to 200 mcg/mL; use undiluted if giving 20 mg/100 mL in D5W
IV Administration
Injection: Administer slowly over 10 minutes; may use undiluted for initial direct IV injection
Infusion: Administer via calibrated electronic controlled-infusion device
Contra Indications
Heart valve stenosis, acute myocardial infarction.
Precautions
Severe obstructive aortic or pulmonary valvular disease, hypertrophic cardiomyopathy, atrial flutter or fibrillation. Monitor blood pressure, heart rate, ECG, fluid and electrolyte balance. Pregnancy and lactation. Use for >48 hr.
Pregnancy-Lactation
Interactions
Potentially Fatal: Avoid anagrelide due the potential for increased inotropic effects.
Adverse Effects
Side effects of Milrinone :
Angina-like chest pain, headache, hypokalaemia, tremor, thrombocytopenia, bronchospasm.
Potentially Fatal: Supraventricular and ventricular arrhythmias; hypotension.
Mechanism of Action
Milrinone is a selective phosphodiesterase III inhibitor with positive inotropic and vasodilator activity. It selectively inhibits cyclic adenosine monophosphate (cAMP) phosphodiesterase activity in cardiac and vascular muscles resulting in increased intracellular concentrations of cAMP. It also acts directly on vascular smooth muscle.
Note
Milrineon 10 10mg Injection manufactured by Neon Laboratories Ltd. Its generic name is Milrinone. Milrineon 10 is availble in Nepal.
Farmaco Nepal drug index information on Milrineon 10 Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.