Minipress XL Tablet
Prazosin
5mg
Pfizer Ltd.
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 17.15 NPR |
Available as:
Indications
Minipress XL Tablet is used for:
Hypertension, Benign prostatic hyperplasia; Raynaud's syndrome
Adult Dose
Oral
Hypertension
Adult: Initially, 0.5 mg bid or tid for 3-7 days, increased to 1 mg bid or tid for the next 3-7 days, and gradually increased thereafter according to patient's response. Max: 20 mg/day in divided doses.
Benign prostatic hyperplasia;
Adult: Initially, 0.5 mg bid, increased to a maintenance dose not exceeding 2 mg bid.
Raynaud Phenomenon
1-5 PO q12hr
Elderly: Dose reduction needed.
Hepatic impairment: Dose reduction needed.
Child Dose
Renal Dose
Renal impairment: Dose reduction needed.
Administration
May be taken with or without food. Starting dose is best taken w/ dinner, at least 2-3 hr before retiring. Maintenance doses may be taken w/ or w/o meals.
Contra Indications
Congestive heart failure due to mechanical obstruction. Hypersensitivity. Pregnancy.
Precautions
Prostate cancer should be ruled out before starting therapy. Patients w/ history of micturition syncope, angina pectoris. Treatment of heart failure due to mechanical obstruction (e.g. aortic or mitral valve stenosis, pulmonary embolism and restrictive pericardial disease). During cataract surgery, Intraoperative Floppy Iris Syndrome (IFIS) may occur. Renal and hepatic impairment. Elderly. Pregnancy and lactation. Patient Counselling May impair ability to drive or operate machinery. A low starting dose is given in the evening to lessen the risk of collapse. Hypotensive effects may be exaggerated by exercise and heat. Monitoring Parameters Monitor renal function. Careful monitoring of BP during initial titration or subsequent upward dosage adjustment.
Lactation: Excreted in breast milk; use caution
Pregnancy-Lactation
Interactions
Hypotensive effects may be enhanced w/ diuretics and other antihypertensives. Increased risk of 1st dose hypotension w/ ?-blockers or Ca channel blockers. Concomitant admin w/ phosphodiesterase type 5 (PDE5) inhibitors (e.g. sildenafil) may result in additive hypotensive effects and symptomatic hypotension.
Adverse Effects
Side effects of Prazosin :
1-10%
Dizziness (10%),Drowsiness (8%),Headache (8%),Weakness (7%),Asthenia (6.5%),Nausea (5%),Palpitation (5%)
Frequency Not Defined (Selected)
Edema,Orthostatic hypotension,Syncope,Fever,Rash,Abdominal discomfort/pain,Diarrhea,Vomiting,Abnormal liver function tests,Impotence,Pancreatitis,Urinary incontinence
Potentially Fatal: Rarely, hypotension may be life-threatening.
Mechanism of Action
Prazosin competitively blocks postsynaptic ?1-adrenoceptors of veins and arterioles causing vasodilation, reduction in BP and total peripheral resistance usually w/o reflex tachycardia.
Note
Minipress XL 5mg Tablet manufactured by Pfizer Ltd.. Its generic name is Prazosin. Minipress XL is availble in Nepal.
Farmaco Nepal drug index information on Minipress XL Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.