Modalert Tablet
Modafinil
200mg
Sun Pharmaceutical Industries Ltd.
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| Retail Price | 30.40 NPR |
Available as:
Indications
Modalert Tablet is used for:
Narcolepsy; Obstructive sleep apnoea
Adult Dose
Oral
Narcolepsy; Obstructive sleep apnoea
Adult: 200-400 mg daily as a single dose in the morning or in 2 divided doses (in the morning and at midday).
Elderly: Initially, 100 mg daily.
Hepatic impairment: Severe: Reduce total dose to 100-200 mg daily.
Shift-work sleep disorder
Adult: 200 mg as a single dose 1 hr before starting work.
Child Dose
Renal Dose
Renal impairment: Severe: Reduce total dose to 100-200 mg daily.
Administration
May be taken with or without food.
Contra Indications
Uncontrolled moderate to severe hypertension or cardiac arrhythmias; history of left ventricular hypertrophy or ischaemic ECG changes, chest pain, any clinical signs of mitral valve prolapse.
Precautions
History of psychosis, depression, mania. Discontinue use if there is any sign of rash or hypersensitivity reaction. Increase monitoring in patients with hypertension. Hepatic and renal impairment. Tourette's syndrome. May impair ability to drive or operate machinery. Pregnancy and lactation.
Pregnancy-Lactation
Interactions
May increase metabolism of ciclosporin, oral contraceptives. May increase the levels/effects of warfarin, TCAs and CYP2C19 substrates (e.g. citalopram, diazepam, methsuximide, phenytoin, propranolol, sertraline). Levels/effects may be reduced with CYP3A4 inducers (e.g. aminoglutethimide, carbamazepine, nafcillin, nevirapine, phenobarbital, phenytoin, rifamycins). Levels/effects may be increased with CYP3A4 inhibitors (e.g. azole antifungals, clarithromycin, diclofenac, doxycycline, erythromycin, imatinib, isoniazid, nefazodone, nicardipine, propofol, protease inhibitors, quinidine, telithromycin, verapamil). Avoid alcohol.
Adverse Effects
Side effects of Modafinil :
Headache, nervousness, insomnia, agitation, confusion, personality disorders, tremor, anxiety; GI disturbances; hypertension, palpitations, tachycardia; angioedema; psychosis, depression, mania, abnormal LFTs.
Potentially Fatal: Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis.
Mechanism of Action
The mechanism of modafinil is unknown but it appears to exert its stimulant effects by reducing GABA-mediated neurotransmission.
Note
Modalert 200mg Tablet manufactured by Sun Pharmaceutical Industries Ltd.. Its generic name is Modafinil. Modalert is availble in Nepal.
Farmaco Nepal drug index information on Modalert Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.