Monopas Tablet
Para-aminosalicylic acid (4-Aminosalicylic acid)
Macleods Pharmaceuticals Pvt. Ltd.
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Indications
Monopas Tablet is used for:
Tuberculosis, Crohn's disease, Ulcerative colitis
Adult Dose
Oral
Tuberculosis
Adult: 150 mg/kg/day in 3-4 equally divided doses
Crohn's disease
Adult: 1.5 g/day (unlabelled use).
Rectal
Ulcerative colitis
Adult: 2 g once a day as an enema in patients who are intolerant to sulphasalazine.
Child Dose
Oral
Tuberculosis
Child: 200-300 mg/kg/day (max: 10 mg) in 3-4 equally divided doses.
Renal Dose
Oral
Tuberculosis
Renal impairment: Haemodialysis: Administer dose afterwards and give 50% dose. Continuous arteriovenous haemofiltration: give 50% dose.
CrCl (ml/min) Dosage Recommendation
10-50 50-75% dose.
<10 50% dose.
Crohn's disease
Adult: 1.5 g/day (unlabelled use).
Renal impairment: Haemodialysis: Administer dose afterwards and give 50% dose. Continuous arteriovenous haemofiltration: give 50% dose.
CrCl (ml/min) Dosage Recommendation
10-50 50-75% dose.
<10 50% dose.
Rectal
Ulcerative colitis
Renal impairment: Haemodialysis: Administer dose afterwards and give 50% dose. Continuous arteriovenous haemofiltration: give 50% dose.
CrCl (ml/min) Dosage Recommendation
10-50 50-75% dose.
<10 50% dose.
Administration
Take with acidic food (e.g. apple sauce, yoghurt, orange juice).
Contra Indications
Hypersensitivity, severe renal disease, G6PD deficiency
Precautions
Renal and hepatic impairment, sodium salt in heart failure; gastric ulcer. Monitor patient closely for 1st 3 mth of treatment and counsel to report: sore throat, fever, unusual bleeding or bruising, persistent nausea or vomiting, or abdominal pain, Pregnancy, lactation
Pregnancy-Lactation
Interactions
May decrease absorption of digoxin and vitamin B12; additive adverse effects of aminosalicylates and salicylates; probenecid may increase toxicity by delaying renal excretion and enhancing plasma concentrations of aminosalicylate; activity of aminosalicylic acid may be antagonised by ester-type local anaesthetics such as procaine; may enhance effect of oral anticoagulants (may need to adjust dose); ammonium chloride may increase risk of crystalluria (do not use concurrently).
Adverse Effects
Side effects of Para-aminosalicylic acid (4-Aminosalicylic acid) :
Nausea, vomiting, diarrhoea, abdominal pain; thyroid goitre, hypoglycaemia; pericarditis, vasculitis; encephalopathy, fever, skin eruptions, agranulocytosis, haemolytic anaemia, leucopenia, thrombocytopenia, hepatitis, jaundice, optic neuritis, eosinophilic pneumonia.
Mechanism of Action
Para-aminosalicylic acid (also known as aminosalicyclic acid) is bacteriostatic and active against M. tuberculosis. Other mycobacteria are usually resistant. It prevents plate biosynthesis in sensitive organisms. It has a relatively weak action compared with other anti-TB drugs and resistance may develop quickly if it is used alone, however it is still sometimes used in multi-drug resistant tuberculosis in combination with other anti-TB drugs.
Note
Monopas Tablet manufactured by Macleods Pharmaceuticals Pvt. Ltd.. Its generic name is Para-aminosalicylic acid (4-Aminosalicylic acid). Monopas is availble in Nepal.
Farmaco Nepal drug index information on Monopas Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.