Monotin Tablet

Isosorbide Dinitrate
10mg
Organon (India) Ltd
Pack size
Dispensing mode
Source
Agent
Retail Price 2.00 NPR

Indications

Monotin Tablet is used for: Angina, Percutaneous transluminal coronary angioplasty

Adult Dose

Angina Pectoris Immediate release: 5-20 mg PO q8-12hr initially; maintenance: 10-40 mg PO q8-12hr

Child Dose

Renal Dose

Administration

Should be taken on an empty stomach. Take on an empty stomach ½ hr before meals.

Contra Indications

Severe hypotension or anaemia, hypovolaemia, heart failure due to obstruction, or raised intracranial pressure due to head trauma or cerebral haemorrhage.

Precautions

Raised intracranial pressure, hypotension, hypovolaemia. Mitral valve prolapse, arterial hypoxaemia, glaucoma, elderly, hypothyroidism, malnutrition, pregnancy, lactation Lactation: Unknown whether drug is distributed into breast milk

Pregnancy-Lactation

Interactions

Increased hypotensive effects with alcohol or vasodilators. Marked orthostatic hypotension may occur when used with calcium channel blockers. Vasodilatory effect may be reduced with dihydroergotamine. Ergotamine effects may be enhanced. Reduced effectiveness of sublingual form with disopyramide. Potentially Fatal: Significant hypotension may occur with phosphodiesterase-5 inhibitors.

Adverse Effects

Side effects of Isosorbide Dinitrate : Cardiovascular: Rebound hypertension (uncommon), syncope, unstable angina flushing, hypotension/orthostatic hypotension, lightheadedness, palpitations, tachyarrhythmia Central nervous system (CNS): Dizziness, headache, restlessness, weakness Gastrointestinal (GI): Nausea Hematologic: Methemoglobinemia (infrequent) Potentially Fatal: Severe hypotension, circulatory collapse.

Mechanism of Action

Isosorbide dinitrate relaxes vascular smooth muscles by stimulating cyclic-GMP. It decreases left ventricular pressure (preload) and arterial resistance (afterload).

Note

Monotin 10mg Tablet manufactured by Organon (India) Ltd. Its generic name is Isosorbide Dinitrate. Monotin is availble in Nepal. Farmaco Nepal drug index information on Monotin Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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