N SOLONE Syrup
Prednisolone
5ML
National Healthcare Pvt. Ltd.
| Pack size | 1's |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 65.00 NPR |
Indications
N SOLONE Syrup is used for:
Rheumatoid arthritis, Multiple sclerosis, Allergic and inflammatory disorders, Nephrotic syndrome, Idiopathic thrombocytopenic purpura, Joint inflammations, Moderate to severe asthma, Infantile spasms
Adult Dose
Oral
Allergic and inflammatory disorders
Adult: 5-60 mg daily in 2-4 divided doses. Maintenance: 2.5-15 mg daily. Withdrawal should be gradual after long-term therapy.
Poorly controlled, moderate to severe asthma, COPD
Adult: Patients with at least 2 exacerbations/yr requiring oral corticosteroids: 40-60 mg daily in 1-2 divided doses; usually given as a short course treatment over 10-14 days until symptom resolution and patient achieves a peak expiratory flow (PEF) of at least 80% of his or her personal best.
Rheumatoid arthritis
Adult: Initially, 5-7.5 mg daily, adjusted as necessary.
Elderly: 5 mg daily.
Multiple sclerosis
Adult: 200 mg daily for 1 wk followed by 80 mg every other day for 1 mth.
Bells Palsy
60 mg PO qDay for 5 days; then taper down by 10 mg daily for 5 days for total duration time of 10 days
Child Dose
Inflammation
0.1-2 mg/kg/day PO in single daily dose or divided q6-12hr; not to exceed 80 mg/day
Acute Asthma
1-2 mg/kg/day in single daily dose or divided q12hr for 3-5 days
Nephrotic Syndrome
First 4 weeks: 60 mg/m²/day or 2 mg/kg/day PO divided q8hr until urine is protein free for 3 consecutive days; not to exceed 28 days; dose not to exceed 80 mg/day
Subsequent 4 weeks: 40 mg/m² or 1-1.5 mg/kg PO every other day; not to exceed 80 mg/day
Maintenance in frequent relapses: 0.5-1 mg/kg/dose PO every other day for 3-6 months
Idiopathic thrombocytopenic purpura
Child: 1-10 yr: 1-2 mg/kg daily (max: 14 days) or 4 mg/kg daily (max: 4 days).
Renal Dose
Administration
Should be taken with food.
Contra Indications
Live vaccines; herpes simplex keratitis, systemic infections.
Precautions
Patients with hypothyroidism, cirrhosis, ulcerative colitis, CHF, convulsive disorders, thrombophlebitis, peptic ulcer, elderly. DM, hypertension, psychological disturbances, osteoporosis; pregnancy, lactation. Adrenal suppression and infection. May cause irreversible growth retardation, glaucoma, corneal perforation.
Lactation: Excreted in breast milk; use caution
Pregnancy-Lactation
Interactions
Efficacy may be reduced by phenytoin, phenobarb, rifampicin. Corticoids may reduce the effects of diuretics, hypoglycaemics, anticholinesterases, salicylates.
Adverse Effects
Side effects of Prednisolone :
Acne,Adrenal suppression,Delayed wound healing,Diabetes mellitus,GI perforation,Glucose intolerance,Hepatomegaly,Hypokalemic alkalosis,Increased transaminases,Insomnia,Menstrual irregularity,Myopathy,Neuritis,Osteoporosis,Peptic ulcer,Perianal pruritus,Pituitary adrenal axis suppression,Pseudotumor cerebri (on withdrawal),Psychosis,Seizure,Ulcerative esophagitis,Urticaria,Vertigo,Weight gain
Potentially Fatal: Acute adrenal insufficiency precipitated by infection, trauma or surgery in patients on long-term therapy or following cessation of such therapy. CV collapse following rapid IV injection.
Mechanism of Action
Prednisolone decreases inflammation by inhibition of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability. It suppresses the immune system by reducing the activity and production of the lymphocytes and eosinophils.
Note
N SOLONE 5ML Syrup manufactured by National Healthcare Pvt. Ltd.. Its generic name is Prednisolone. N SOLONE is availble in Nepal.
Farmaco Nepal drug index information on N SOLONE Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.