NACYRES Syrup

Acetylcysteine
600MG
Stancare
Pack size 1's
Dispensing mode
Source
Agent
Retail Price 28.64 NPR

Indications

NACYRES Syrup is used for: Tuberculosis, Chronic emphysema, Paracetamol poisoning, Bronchiectasis, Pneumonia, Atelectasis, Cystic fibrosis, Tracheostomy care, during anaesthesia

Adult Dose

Oral As a mucolytic Adult: As effervescent granules or tablets: 200 mg tid. Paracetamol poisoning Adult: After gastric lavage or induction of emesis with ipecac syrup, admin loading dose of 140 mg/kg, followed by maintenance doses of 70 mg/kg every 4 hr for a total of 17 doses. 1st maintenance dose to be given 4 hr after the loading dose. Repeat dose if the patient vomits within 1 hr of admin. Continue therapy until paracetamol levels are not detectable and there is no evidence of hepatotoxicity. Inhalation As a mucolytic Adult: 3-5 ml of a 20% solution or 6-10 ml of a 10% solution 3-4 times daily by nebulising through a face mask, mouth piece or tracheostomy. May increase to 1-10 ml of a 20% solution or 2-20 ml of a 10% solution every 2-6 hr if needed. Endotracheal As a mucolytic Adult: Instill 1-2 ml of a 10-20% solution as often as every hrly. Intravenous Paracetamol poisoning Adult: Initially, 150 mg/kg (max: 16.5 g) in 200 mL diluent over 60 min, followed by 50 mg/kg (max: 5.5 g) in 500 mL diluent over the next 4 hr, then 100 mg/kg (max: 11 g) in 1 L diluent over the next 16 hr.

Child Dose

Oral As a mucolytic Child: As effervescent granules or tablets: 2-7 yr: 200 mg bid; <2 yr: 200 mg daily. Paracetamol poisoning Child: After gastric lavage or induction of emesis with ipecac syrup, admin loading dose of 140 mg/kg, followed by maintenance doses of 70 mg/kg every 4 hr for a total of 17 doses. 1st maintenance dose to be given 4 hr after the loading dose. Repeat dose if the patient vomits within 1 hr of admin. Continue therapy until paracetamol levels are not detectable and there is no evidence of hepatotoxicity. Inhalation As a mucolytic Child: 3-5 ml of a 20% solution or 6-10 ml of a 10% solution 3-4 times daily by nebulising through a face mask, mouth piece or tracheostomy. May increase to 1-10 ml of a 20% solution or 2-20 ml of a 10% solution every 2-6 hr if needed. Endotracheal As a mucolytic Child: Instill 1-2 ml of a 10-20% solution as often as every hrly. Intravenous Paracetamol poisoning Child: <20 kg: Initially, 150 mg/kg in 3 mL/kg diluent over 60 min, followed by 50 mg/kg in 7 mL/kg diluent over 4 hr, then 100 mg/kg in 14 mL/kg diluent over 16 hr; 20-40 kg: Initially, 150 mg/kg in 100 mL diluent over 60 min, followed by 50 mg/kg in 250 mL diluent over 4 hr, then 100 mg/kg in 500 mL diluent over 16 hr; >40 kg: Same as adult dose.

Renal Dose

Administration

Contra Indications

Acetylcysteine is contraindicated in those patients who are sensitive to it.

Precautions

Asthmatic patients, history of bronchospasm, peptic ulceration. Pregnancy, lactation. Lactation: Unknown whether agent is excreted in milk; use with caution.

Pregnancy-Lactation

Interactions

Drug stability and safety of acetylcysteine when mixed with other drugs in a nebulizer have not been established.

Adverse Effects

Side effects of Acetylcysteine : Flushing, fever, stomatitis, nausea, vomiting, rhinorrhoea, bronchospasm, anaphylactoid reactions, rashes. Rarely, blurred vision, bradycardia, syncope, thrombocytopenia, convulsions. Potentially Fatal: Rarely, respiratory or cardiac arrest.

Mechanism of Action

Acetylcysteine may decrease the viscosity of secretions by splitting of disulphide bonds in mucoproteins. It also promotes the detoxification of an intermediate paracetamol metabolite which is used in the management of paracetamol overdosage.

Note

NACYRES 600MG Syrup manufactured by Stancare. Its generic name is Acetylcysteine. NACYRES is availble in Nepal. Farmaco Nepal drug index information on NACYRES Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Acetylcysteine :