Nebanol Powder
Bacitracin Zinc + Neomycin Sulphate Topical
(4.18 mg+5 mg)/gm
Square Pharmaceuticals Ltd.
| Pack size | 1's Pack (10 gm) |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 71.50 NPR |
Indications
Nebanol Powder is used for:
Bacterial skin infections
Adult Dose
Adult: Topical: Cream: Apply 3 times/day.
Powder: Apply 2-4 times/day.
Child Dose
Topical: Cream: Apply 3 times/day.
Powder: Apply 2-4 times/day.
Renal Dose
Administration
Contra Indications
Hypersensitivity to aminoglycosides. Pre-existing nerve deafness. Neonates and infants <2 yr.
Precautions
Avoid application in large quantities and prolonged use. Pregnancy and lactation. Liver and renal impairment.
Pregnancy-Lactation
Interactions
Bacitracin Zinc: Increased risk of nephrotoxicity when used with other nephrotoxic drugs. May enhance the action of neuromuscular-blocking agents.
Neomycin Sulphate: Additive nephrotoxic and neurotoxic effect w/ other aminoglycosides (e.g. paromomycin), bacitracin, cisplatin, vancomycin, amphotericin B, polymyxin B, colistin and viomycin. Enhanced toxicity w/ potent diuretics (e.g. ethacrynic acid, furosemide). May impair the absorption of other drugs (e.g. phenoxymethylpenicillin, digoxin, methotrexate and some vit). May reduce the efficacy of OCs. May enhance the effect of acarbose. May enhance the effect of non-depolarising muscle relaxants. May antagonise the parasympathomimetic effect of neostigmine and pyridostigmine. May increase the risk of hypocalcaemia in patients receiving bisphosphonates. May alter INR when given w/ anticoagulants. May inactivate oral typhoid vaccine.
Adverse Effects
Side effects of Bacitracin Zinc + Neomycin Sulphate Topical :
>10%
Allergic contact dermatitis (60%)
Mechanism of Action
Neomycin, an aminoglyoside with antimicrobial spectrum similar to gentamicin, binds to the 30S subunits of the bacterial ribosome, inhibiting protein synthesis and thereby disrupting DNA synthesis. It is active against many gram-negative aerobes and against some strains of staphylococci. Bacitracin, on the other hand, inhibits bacterial cell wall synthesis and is active against many gram-positive bacteria (e.g. staphylococci, streptococci, corynebacteria and clostridia) and some gram-negative species (e.g. Neisseria and Haemophilus influenzae). They are often found in combinations in topical preparations as broad spectrum antibacterial agents.
Note
Nebanol (4.18 mg+5 mg)/gm Powder manufactured by Square Pharmaceuticals Ltd.. Its generic name is Bacitracin Zinc + Neomycin Sulphate Topical. Nebanol is availble in Nepal.
Farmaco Nepal drug index information on Nebanol Powder is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.