Neosporin H Ear Drop
Polymyxin B + Neomycin Ear prep
(10000 u)+(3400 u)
Glaxo SmithKline Pharmaceuticals Ltd.
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Indications
Neosporin H Ear Drop is used for:
Otitis externa
Adult Dose
Otic/Aural
Otitis externa
Adult: Instill 3 drops into affected ear(s) 3-4 times daily.
Alternatively, insert a gauze wick into the canal and keep it saturated with the solution for 24-48 hours.
Discontinue if there is no clinical improvement after 7 days.
Child Dose
Otic/Aural
Otitis externa
Child: >3 years
Instill 3 drops into affected ear(s) 3-4 times daily.
Alternatively, insert a gauze wick into the canal and keep it saturated with the solution for 24-48 hours.
Discontinue if there is no clinical improvement after 7 days.
Renal Dose
Renal impairment: Dosage reduction may be necessary.
Administration
Contra Indications
Hypersensitivity to polymyxin B, neomycin and hydrocortisone and other aminoglycosides. Perforated tympanic membrane, untreated viral, fungal and tubercular infections. Children <3 years.
Precautions
Patient with conditions where significant systemic absorption may occur, venous stasis eczema and ulceration, pre- and post-operative period. Prolonged use. Children. Pregnancy and lactation.
Pregnancy-Lactation
Interactions
Neomycin and polymyxin may increase risk of respiratory depression with neuromuscular blocking agents.
Adverse Effects
Side effects of Polymyxin B + Neomycin Ear prep :
Significant: Irreversible ototoxicity (e.g. deafness), nephrotoxicity, neurotoxicity, neomycin sensitisation (e.g. itching, reddening, oedema, failure to heal), immunosuppression, Kaposi sarcoma, and suppression of the pituitary-adrenal (HPA) axis after systemic absorption. Ear and labyrinth disorders: Stinging, burning sensation in ears.
Potentially Fatal: Pseudomembranous colitis.
Mechanism of Action
Polymyxin B is a bactericidal active against a wide range of gram negative bacilli. It binds to acid phospholipids in the bacterial cytoplasmic membrane, thereby altering permeability and disrupting the osmotic barrier leading to cell death.
Neomycin, an aminoglycoside, is a bactericidal active against a wide range of gram positive and gram negative bacteria. It interferes with bacterial protein synthesis by binding to 30S ribosomal subunits
Note
Neosporin H (10000 u)+(3400 u) Ear Drop manufactured by Glaxo SmithKline Pharmaceuticals Ltd.. Its generic name is Polymyxin B + Neomycin Ear prep. Neosporin H is availble in Nepal.
Farmaco Nepal drug index information on Neosporin H Ear Drop is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.