Nepex PAED Solution

Dextromethorphan + Chlopheniramine + Pseudoepedrine
7.5mg + 15mg + 1mg
Nepal Pharmaceuticals Pvt. Ltd.
Pack size
Dispensing mode
Source
Agent
Retail Price 40.00 NPR

Indications

Nepex PAED Solution is used for: Temporary relief of cough and upper respiratory tract symptoms, including nasal and sinus congestion; sneezing; itchy nose or throat; runny nose; and itchy, watery eyes associated with allergy or common cold.

Adult Dose

Relief of Cold & Fever 10 mL [(2mg/15mg/15mg)/5mL] PO q6hr; not to exceed 40 mL/day 10 mL [(2mg/10mg/30mg)/5mL] PO q4-6hr; not to exceed 40 mL/day 5 mL [(4mg/20mg/20mg)/5mL] PO q4-6hr; not to exceed 30 mL/day

Child Dose

Relief of Cold & Fever 6-12 Years Old 2 mL [(0.8mg/3mg/8mg)/1mL] PO q4-6hr; not to exceed 8 mL/24hr 10 mL [(1mg/5mg/15mg)/5mL] PO q4-6hr; not to exceed 40 mL/24hr 5 mL [(2mg/15mg/15mg)/5mL] PO q4-6hr; not to exceed 20 mL/24hr 2.5 mL [(4mg/20mg/20mg)/5mL] PO q4-6hr; not to exceed 15 mL/24hr >12 Years Old 10 mL [(2mg/15mg/15mg)/5mL] PO q6hr; not to exceed 40 mL/day 10 mL [(2mg/10mg/30mg)/5mL] PO q4-6hr; not to exceed 40 mL/day 5 mL [(4mg/20mg/20mg)/5mL] PO q4-6hr; not to exceed 30 mL/day

Renal Dose

Use with caution.

Administration

Contra Indications

Hypersensitivity to any ingredients of product; severe hypertension; severe coronary artery disease; ischemic heart disease; narrow-angle glaucoma; urinary retention; peptic ulcer; emphysema; chronic bronchitis; as treatment for lower respiratory tract conditions, including asthma; during an asthma attack; concomitant MAOI therapy or for 2 wk after stopping MAOI therapy; newborns or premature infants; pregnancy; breast-feeding mothers.

Precautions

Caution in cardiovascular disease, diabetes mellitus, prostatic hypertrophy and increased intraocular pressure when taking pseudoephedrine Do not take dextromethorphan for persistent or chronic cough associated with smoking, asthma, or emphysema, or if it is accompanied by excessive phlegm unless directed by a healthcare provider; may decrease respiration rate Chlorpheniramine may cause significant confusional symptoms; not for administration to premature or full-term neonates Lactation: excretion in milk unknown/not recommended

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Dextromethorphan + Chlopheniramine + Pseudoepedrine : Arrhythmia,Hypertension,Hypotension,Palpitations,Reflex tachycardia,Severe peripheral and visceral vasoconstriction,Tachycardia,Confusion,Depression,Distress,Dizziness,Drowsiness,Excitability,Euphoria,Fatigue,Headache,Insomnia,Irritability,Restlessness,Sedation,Tremor,Anorexia,GI disturbances,Agranulocytosis,Hemolytic anemia,Thrombocytopenia,Thickening of bronchial secretions,Wheezing

Mechanism of Action

Chlorpheniramine blocks muscle responses in histamine and acts as an antagonism of the constrictor effects of histamine on respiratory smooth muscle. Dextromethorphan is a cough suppressant that acts centrally on the cough center in medulla Pseudoephedrine stimulates the alpha-adrenergic receptors causing bronchodilation and vasoconstriction.

Note

Nepex PAED 7.5mg + 15mg + 1mg Solution manufactured by Nepal Pharmaceuticals Pvt. Ltd.. Its generic name is Dextromethorphan + Chlopheniramine + Pseudoepedrine. Nepex PAED is availble in Nepal. Farmaco Nepal drug index information on Nepex PAED Solution is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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