Nepex PAED Solution
Dextromethorphan + Chlopheniramine + Pseudoepedrine
7.5mg + 15mg + 1mg
Nepal Pharmaceuticals Pvt. Ltd.
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| Retail Price | 40.00 NPR |
Indications
Nepex PAED Solution is used for:
Temporary relief of cough and upper respiratory tract symptoms, including nasal and sinus congestion; sneezing; itchy nose or throat; runny nose; and itchy, watery eyes associated with allergy or common cold.
Adult Dose
Relief of Cold & Fever
10 mL [(2mg/15mg/15mg)/5mL] PO q6hr; not to exceed 40 mL/day
10 mL [(2mg/10mg/30mg)/5mL] PO q4-6hr; not to exceed 40 mL/day
5 mL [(4mg/20mg/20mg)/5mL] PO q4-6hr; not to exceed 30 mL/day
Child Dose
Relief of Cold & Fever
6-12 Years Old
2 mL [(0.8mg/3mg/8mg)/1mL] PO q4-6hr; not to exceed 8 mL/24hr
10 mL [(1mg/5mg/15mg)/5mL] PO q4-6hr; not to exceed 40 mL/24hr
5 mL [(2mg/15mg/15mg)/5mL] PO q4-6hr; not to exceed 20 mL/24hr
2.5 mL [(4mg/20mg/20mg)/5mL] PO q4-6hr; not to exceed 15 mL/24hr
>12 Years Old
10 mL [(2mg/15mg/15mg)/5mL] PO q6hr; not to exceed 40 mL/day
10 mL [(2mg/10mg/30mg)/5mL] PO q4-6hr; not to exceed 40 mL/day
5 mL [(4mg/20mg/20mg)/5mL] PO q4-6hr; not to exceed 30 mL/day
Renal Dose
Use with caution.
Administration
Contra Indications
Hypersensitivity to any ingredients of product; severe hypertension; severe coronary artery disease; ischemic heart disease; narrow-angle glaucoma; urinary retention; peptic ulcer; emphysema; chronic bronchitis; as treatment for lower respiratory tract conditions, including asthma; during an asthma attack; concomitant MAOI therapy or for 2 wk after stopping MAOI therapy; newborns or premature infants; pregnancy; breast-feeding mothers.
Precautions
Caution in cardiovascular disease, diabetes mellitus, prostatic hypertrophy and increased intraocular pressure when taking pseudoephedrine
Do not take dextromethorphan for persistent or chronic cough associated with smoking, asthma, or emphysema, or if it is accompanied by excessive phlegm unless directed by a healthcare provider; may decrease respiration rate
Chlorpheniramine may cause significant confusional symptoms; not for administration to premature or full-term neonates
Lactation: excretion in milk unknown/not recommended
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Dextromethorphan + Chlopheniramine + Pseudoepedrine :
Arrhythmia,Hypertension,Hypotension,Palpitations,Reflex tachycardia,Severe peripheral and visceral vasoconstriction,Tachycardia,Confusion,Depression,Distress,Dizziness,Drowsiness,Excitability,Euphoria,Fatigue,Headache,Insomnia,Irritability,Restlessness,Sedation,Tremor,Anorexia,GI disturbances,Agranulocytosis,Hemolytic anemia,Thrombocytopenia,Thickening of bronchial secretions,Wheezing
Mechanism of Action
Chlorpheniramine blocks muscle responses in histamine and acts as an antagonism of the constrictor effects of histamine on respiratory smooth muscle.
Dextromethorphan is a cough suppressant that acts centrally on the cough center in medulla
Pseudoephedrine stimulates the alpha-adrenergic receptors causing bronchodilation and vasoconstriction.
Note
Nepex PAED 7.5mg + 15mg + 1mg Solution manufactured by Nepal Pharmaceuticals Pvt. Ltd.. Its generic name is Dextromethorphan + Chlopheniramine + Pseudoepedrine. Nepex PAED is availble in Nepal.
Farmaco Nepal drug index information on Nepex PAED Solution is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.