Nepofen Plus Gel
Diclofenac Diethylamine + Linseed Oil + Methyl Salicylate + Menthol Topical
Deurali Janta Pharmaceuticals Pvt. Ltd.
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Indications
Nepofen Plus Gel is used for:
Frozen shoulder, sport injuries, bruises, myositis, tenosynovitis, fibrositis, low back pain, spondylitis, arthropathies & arthritis pain.
Adult Dose
Topical
Adult
2-4 g rubbed gently into the affected area, tid or qid.
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity. Aspirin-induced bronchial asthma. Avoid use on broken skin, & open wound. Childn <12 yr.
Precautions
Hypersensitivity to local use of ASA, different salicylates & other NSAIDs. Patients w/ stomach or intestinal ulcer, liver & kidney disorders, haematological disorders, nasal polyposis relapse. Do not apply on damaged skin. Wash hands after use; avoid contact w/ eyes & mucous tunics. Do not apply on big areas of the body, or use for a long time in the last 3 mth of pregnancy & during lactation. Neonates.
Pregnancy-Lactation
Interactions
Increased effect of anticoagulants, GCS, lithium. Decreased action of furosemide, thiazide diuretics. Increased digoxin plasma conc; decreased tolerance, & increased ulcerogenic action on GIT mucous coat of other NSAIDs. Local skin irritation (urticaria, reddening, desquamation) in concurrent use w/ N-acylethanolamine acid amidase (NAAA)-containing medicines
Adverse Effects
Side effects of Diclofenac Diethylamine + Linseed Oil + Methyl Salicylate + Menthol Topical :
Skin irritation, eg, skin rash, oedema, wheals, papules, scutes, reddening, burning, prickling, itch at the application site.
Mechanism of Action
Diclofenac inhibits the cyclooxygenase, suppresses synthesis of prostaglandins-endogenous substances, which play a significant role in the genesis of the inflammation, pain, and fever. Diclofenac reduces pain, eliminates inflammation.
Menthol acts on the temperature receptors. It gives sensation of coolness, constricts capillaries, and decreases their permeability. It provides local counter-irritation and gentle analgesic actions.
Methyl salicylate is a derivative of salicylic acid, which has local irritation action. Methyl salicylate decreases the pain because of irritation of skin receptors. Methyl salicylate inhibits synthesis of prostaglandins, decreases swelling and infiltration of inflamed tissues.
Linseed oil is alfalinoleic acid, which has anti-inflammatory, antioxidant actions, improves blood circulation at place of application.
The action of medicine begins within few minutes after application on skin. During 20-30 min it achieves maximum activity level. It provides relief from the symptoms from day one of beginning of treatment.
Note
Nepofen Plus Gel manufactured by Deurali Janta Pharmaceuticals Pvt. Ltd.. Its generic name is Diclofenac Diethylamine + Linseed Oil + Methyl Salicylate + Menthol Topical. Nepofen Plus is availble in Nepal.
Farmaco Nepal drug index information on Nepofen Plus Gel is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.