Niko-XL Tablet

Chlorzoxazone + Paracetamol

250mg + 500mg

National Healthcare Pvt. Ltd.

Pack size	15's
Dispensing mode
Source
Agent
Retail Price	7.00 NPR

Indications

Niko-XL Tablet is used for: Adjunctive therapy for pain relief & muscle spasm associated w/ acute, painful musculoskeletal conditions.

Adult Dose

Adult 1-2 tab qds.

Child Dose

Renal Dose

Administration

Should be taken with food.

Contra Indications

Hypersensitivity

Precautions

Hepatic dysfunction. May affect ability to drive or operate machinery. Pregnancy & lactation.

Pregnancy-Lactation

Interactions

Antipsychotics, CNS depressants, alcohol.

Adverse Effects

Side effects of Chlorzoxazone + Paracetamol : GI disturbances, drowsiness, dizziness, malaise, overstimulation, rash.

Mechanism of Action

Paracetamol has analgesic and antipyretic effects similar to those of aspirin. However, it has no anti-inflammatory effect and does not share the antirheumatic properties of the salicylates. It is rapidly and practically completely absorbed from the GIT. The concentration in plasma reaches a peak in 30-60 min and the plasma t½ is about 2 hrs after therapeutic doses. It is distributed into most body tissues. It crosses the placenta and is present in breast milk. Chlorzoxazone is a centrally-acting muscle relaxant. Chlorzoxazone acts primarily at the level of the spinal cord and subcortical areas of the brain where it inhibits multisynaptic reflex arcs involved in producing and maintaining skeletal muscle spasm of varied etiology. Chlorzoxazone is rapidly absorbed from the GIT. It is metabolized to 6-hydroxychlorzoxazone and then eliminated in the urine.

Note

Niko-XL 250mg + 500mg Tablet manufactured by National Healthcare Pvt. Ltd.. Its generic name is Chlorzoxazone + Paracetamol. Niko-XL is availble in Nepal. Farmaco Nepal drug index information on Niko-XL Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Chlorzoxazone + Paracetamol :

Tablet

Myozox ^{250 + 500}

Nepal Pharmaceuticals Pvt. Ltd.

Tablet

Zoxafen ^{250mg + 500mg}

Deurali Janta Pharmaceuticals Pvt. Ltd.

Tablet

Zoxafen Forte ^{500mg + 250mg}

Deurali Janta Pharmaceuticals Pvt. Ltd.

Tablet

Mezorax ^{250mg + 500mg}

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Tablet

Myospaz ^{250mg + 325mg}

Win-Medicare Pvt. Ltd.