Nitrofix Tablet
Isosorbide Mononitrate
10mg
Micro Labs Ltd.
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 3.03 NPR |
Available as:
Indications
Nitrofix Tablet is used for:
Angina pectoris
Adult Dose
Oral
Angina Pectoris
Prevention of angina pectoris caused by coronary artery disease
Adult: 20 mg 2-3 times daily. Dose may range from 20-120 mg daily.
As LA form: One capsule once daily.
Elderly: Intiate at lower doses.
Child Dose
Safety and efficacy not established
Renal Dose
Administration
Should be taken on an empty stomach (i.e. At least one hour before food or two hours after food).
Contra Indications
Severe hypotension or anaemia, hypovolaemia, heart failure due to obstruction, or raised intracranial pressure due to head trauma or cerebral haemorrhage.
Precautions
Severe renal or severe hepatic impairment, hypothyroidism, malnutrition, or hypothermia. Caution in patients who are already hypotensive. May aggravate angina caused by hypertrophic cardiomyopathy. Tolerance may develop after long-term treatment. Lactation.
Lactation: Unknown whether drug crosses into breast milk; use caution
Pregnancy-Lactation
Interactions
Hypotensive effects may be increased when used with alcohol or vasodilators. Concurrent use with calcium channel blockers may lead to marked orthostatic hypotension.
Potentially Fatal: Significant hypotension may occur when used with phosphodiesterase-5 inhibitors.
Adverse Effects
Side effects of Isosorbide Mononitrate :
Hypotension, tachycardia, flushing, headache, dizziness, palpitation, syncope, confusion. Nausea, vomiting, abdominal pain. Restlessness, weakness and vertigo. Dry mouth, chest pain, back pain, oedema, fatigue, abdominal pain, constipation, diarrhoea, dyspepsia and flatulence.
Potentially Fatal: Severe hypotension and cardiac failure.
Mechanism of Action
Isosorbide mononitrate relaxes vascular smooth muscles by stimulating cyclic-GMP. It decreases left ventricular pressure (preload) and arterial resistance (afterload).
Note
Nitrofix 10mg Tablet manufactured by Micro Labs Ltd.. Its generic name is Isosorbide Mononitrate. Nitrofix is availble in Nepal.
Farmaco Nepal drug index information on Nitrofix Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.