NITROVAS Ointment
Nitroglycerin 2% Topical
0.2%W/W
Biogain Remedies Pvt. Ltd.
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| Retail Price | 180.00 NPR |
Indications
NITROVAS Ointment is used for:
Angina Pectoris, Congestive Heart Failure
Adult Dose
Topical/Cutaneous
Stable angina
Adult: As 2% oint: Apply 0.5-2 inches on a convenient area of the skin bid or 3-4 hrly if necessary; cover the area after application.
Congestive Heart Failure
1.5 inches, increase by 0.5-1 inch up to 4 inches, q4hr
Child Dose
Safety and efficacy not established
Renal Dose
Administration
Contra Indications
Hypersensitivity to organic nitrates
Recent use (within several days) of PDE-5 inhibitors (eg, avanafil, sildenafil, tadalafil, or vardenafil) may cause dangerously low hypotension; the time course of the interaction appears to be related to the PDE-5 inhibitor half-life
Riociguat; coadministration may cause hypotension
Narrow angle glaucoma (controversial: may not be clinically significant)
Severe anemia
Precautions
Alcohol use, incr ICP (head trauma, cerebral hemorrhage-potential contraindication), hyperthyroidism, hypertrophic cardiomyopathy, increase IOP, hypotension, volume depletion, low systolic BP
Do not change brands unintentionally as not all are bioequivalent
Treat drug-induced headache with aspirin or acetaminophen
Provide nitrate-free interval (10-12 hr or overnight) to avoid development of tolerance
Discontinue if blurred vision develops
Do not apply with fingers; do not rub or massage
Lactation: not known whether the drug crosses into breast milk, use caution
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Nitroglycerin 2% Topical :
Orthostatic hypotension, peripheral oedema, bradycardia, tachycardia flushing, hypotension, syncope, dizziness, headache, light-headedness, nausea, vomiting, xerostomia, weakness, paraesthesia, diaphoresis, dyspnoea, rhinitis, pharyngitis, allergic reaction.
Mechanism of Action
Organic nitrate which causes systemic venodilation, decreasing preload
Cellular mechanism: nitrate enters vascular smooth muscle and converted to nitric oxide (NO) leading to activation of cGMP & vasodilation
Relaxes smooth muscle via dose-dependent dilation of arterial and venous beds to reduce both preload and afterload, and myocardial O2 demand
Also improves coronary collateral circulation
Lower BP, increase HR, occasional paradoxical bradycardia
Note
NITROVAS 0.2%W/W Ointment manufactured by Biogain Remedies Pvt. Ltd.. Its generic name is Nitroglycerin 2% Topical. NITROVAS is availble in Nepal.
Farmaco Nepal drug index information on NITROVAS Ointment is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.