Norad Injection

Norepinephrine (Noradrenaline)
4mg
Neon Laboratories Ltd
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Indications

Norad Injection is used for: Acute Hypotension, Cardiac Arrest, Sepsis & Septic Shock

Adult Dose

Intravenous Adult: Acute Hypotension, Cardiac Arrest Initial: 8-12 mcg/min IV infusion; titrate to effect Maintenance: 2-4 mcg/min IV infusion Sepsis & Septic Shock 0.01-3 mcg/kg/min IV infusion

Child Dose

Child: Acute Hypotension, Cardiac Arrest Initial: 0.05-0.1 mcg/kg/min IV infusion; titrate to effect Maximum: 1-2 mcg/kg/min Shock 0.05-0.1 mcg/kg/min IV infusion; titrate to effect; not to exceed 2 mcg/kg/min

Renal Dose

Administration

IV Preparation & Administration Infuse using a solution of 4 mcg/ml in glucose 5%, or sodium chloride 0.9% and glucose 5% at a rate of 2-3 ml/minute. Adjust according to BP response. Average maintenance dose: 0.5-1 ml/minute (2-4 mcg/minute). Infuse via a central venous catheter or into a large vein.

Contra Indications

Hypersensitivity. Hypertension. Pregnancy. Patients with peripheral or mesenteric vascular thrombosis unless necessary as a life-saving procedure. Concomitant use with some general anesthetics: Chloroform, trichloroethylene, cyclopropane, halothane

Precautions

Not a substitute for replacement of blood, plasma, fluids, and/or electrolytes; correct volume depletion prior to admin. Identify and correct hypoxia, hypercapnia and acidosis prior to or during admin. Avoid extravasation as tissue necrosis may occur. Avoid inj into leg veins, especially in elderly or those with occlusive vascular diseases, arteriosclerosis, DM or Buerger's disease. Hypertensive or hyperthyroid patients. In conjunction with local anaesthetics, do not use in fingers, toes, ears, nose or genitalia. Lactation. Lactation: Not known if excreted into breast milk; avoid use during breastfeeding

Pregnancy-Lactation

Interactions

Guanethidine, methyldopa, reserpine, TCAs may increase pressor response to norepinephrine. Potentially Fatal: Increased risk of arrhythmias with cocaine, cyclopropane or halogenated hydrocarbon anaesthetics. Hypertensive crisis may occur with MAOIs. Hypertensive effects may be increased by nonselective β-blockers.

Adverse Effects

Side effects of Norepinephrine (Noradrenaline) : Hypertension, headache, peripheral ischaemia, bradycardia, arrhythmias, anxiety, skin necrosis (with extravasation), dyspnoea, respiratory difficulty.

Mechanism of Action

Norepinephrine is a direct-acting sympathomimetic which stimulates alpha 1- and beta-adrenergic receptors. Its alpha-agonist effects cause vasoconstriction, thereby raising systolic and diastolic BP with reflex slowing of heart rate.

Note

Norad 4mg Injection manufactured by Neon Laboratories Ltd. Its generic name is Norepinephrine (Noradrenaline). Norad is availble in Nepal. Farmaco Nepal drug index information on Norad Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Norepinephrine (Noradrenaline) :