Novorapid Cartridge
Insulin Aspart
Novo Nordisk India Pvt Ltd.
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Indications
Novorapid Cartridge is used for:
Diabetes mellitus
Adult Dose
Subcutaneous
Type 1 Diabetes Mellitus
Improvement of glycemic control in adults and children with diabetes mellitus
May administer 0.2-0.6 unit/kg/day in divided doses; conservative doses of 0.2-0.4 unit/kg/day often recommended to reduce risk of hypoglycemia
Total maintenance daily insulin requirement may vary; it is usually between 0.5 and 1 unit/kg/day; nonobese may require 0.4-0.6 unit/kg/day; obese may require 0.6-1.2 units/kg/day
Type 2 Diabetes Mellitus
Diabetes inadequately controlled by diet, weight reduction, exercise, or oral medication
Initial: 0.2-0.4 units/kg/day SC divided q8hr-q12hr.
And an intermediate (eg, NPH) or long-acting insulin at bedtime recommended;
Hepatic impairment: Dosage reduction may be needed.
Dosing Considerations
When used in a meal-related SC injection treatment regimen, 50-75% of total insulin requirements may be provided by an intermediate-acting or long-acting insulin; the remainder is divided and provided before or at mealtimes as a rapid-acting insulin, such as insulin aspart
Dosage must be individualized; blood and urine glucose monitoring is essential in all patients receiving insulin therapy
Child Dose
Subcutaneous
Type 1 Diabetes Mellitus
Improvement of glycemic control in adults and children with diabetes mellitus
>2 years: May require 0.8-1.2 units/kg/day SC during growth spurts; adolescents may require <1.2 units/kg/day; otherwise, may use 0.5-1 unit/kg/day
Renal Dose
Renal impairment: Dose adjustments may be needed.
Administration
SC injection
Should be taken with food. Administer immediately within 5-10 minutes before a meal.
When administered by SC injection, insulin aspart should generally be used in regimens with an intermediate- or long-acting insulin
Administer subcutaneously in the upper arm, thigh or abdominal wall. A subcutaneous injection into the abdominal wall results in a faster absorption than from other injection sites.
Injection sites should be rotated within the same region to reduce the risk of lipodystrophy
Contra Indications
Hypoglycaemia. Hypersensitivity to any of the components.
Precautions
Pregnancy (insulin requirements tend to fall during the 1st trimester, increase during the 2nd and 3rd) and lactation. Caution with decreased insulin requirements: Diarrhea, nausea/vomiting, malabsorption, hypothyroidism, renal impairment, hepatic impairment
Hypokalemia may occur
Use with caution in renal and hepatic impairment (dosage requirements may be reduced)
Caution with increased insulin requirements: Fever, hyperthyroidism, trauma, infection, surgery
Lactation: Safe to use while breastfeeding
Pregnancy-Lactation
Interactions
Effects may be increased by: oral antidiabetic agents, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, propoxyphene, salicylates, somatostatin analog (e.g., octreotide), sulfonamide antibiotics. Effects may be decreased by: corticosteroids, niacin, danazol, diuretics, sympathomimetic agents, isoniazid, phenothiazine derivatives, somatropin, thyroid hormones, oral contraceptives, lithium. Signs of hypoglycaemia may be masked by beta-blockers, clonidine.
Adverse Effects
Side effects of Insulin Aspart :
Allergic reactions. Injection site reaction, lipodystrophy, pruritus, rash, lipoatrophy, hypokalaemia, blurred vision. Hypoglycaemia, insulin resistance.
Mechanism of Action
Insulin aspart, a rapid-acting analog of human insulin, lowers blood glucose levels; it regulates carbohydrate, protein and fat metabolism by inhibiting hepatic glucose production and lipolysis, and enhancing peripheral glucose disposal.
Note
Novorapid Cartridge manufactured by Novo Nordisk India Pvt Ltd.. Its generic name is Insulin Aspart. Novorapid is availble in Nepal.
Farmaco Nepal drug index information on Novorapid Cartridge is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.