Ocucin Eye
Ofloxacin 0.3% E/E drops
0.3%
Sun Pharmaceutical Industries Ltd.
| Pack size | 10ml |
|---|---|
| Dispensing mode | |
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Available as:
Indications
Ocucin Eye is used for:
Bacterial Conjunctivitis, Otic infections, Bacterial corneal ulcer
Adult Dose
Ophthalmic
Bacterial Conjunctivitis ; Keratoconjunctivitis
Adult: Instill 1-2 drops in the affected eye(s) every 2-4 hr for the 1st 2 days, then 4 times daily. Max duration: 10 days.
Corneal Ulcer
Days 1-2: 1-2 drops q30min while awake
Days 3-7: 1-2 drops q1hr while awake
Days 7-9: 1-2 drops 4 times daily until clinical cure
Otic/Aural
Chronic Suppurative Otitis Media With Perforated Tympanic Membranes
Adult: Instill 10 drops into the canal of the affected ear(s) bid for 14 days.
Lie w/ the affected ear upwards for 5 min; pump the targus of the ear 4 times by pushing inward to facilitate penetration of the drops into the ear.
Otitis externa
Adult: Instill 10 drops into the canal of the affected ear(s) once daily for 7 days.
Lie w/ the affected ear upwards for 5 min to facilitate penetration into the ear.
Child Dose
Ophthalmic
Bacterial Conjunctivitis ; Keratoconjunctivitis
Child>1 year: Instill 1-2 drops in the affected eye(s) every 2-4 hr for the 1st 2 days, then 4 times daily. Max duration: 10 days.
Corneal Ulcer
Child >1 year
Days 1-2: 1-2 drops q30min while awake
Days 3-7: 1-2 drops q1hr while awake
Days 7-9: 1-2 drops 4 times daily until clinical cure
Otic/Aural
Chronic Suppurative Otitis Media With Perforated Tympanic Membranes
Child >12 years: Instill 10 drops into the canal of the affected ear(s) bid for 14 days.
Lie w/ the affected ear upwards for 5 min; pump the targus of the ear 4 times by pushing inward to facilitate penetration of the drops into the ear.
Otitis externa
Child >13 years: Instill 10 drops into the canal of the affected ear(s) once daily for 7 days.
Lie w/ the affected ear upwards for 5 min to facilitate penetration into the ear.
Child: 6 m-13 yr: Instill 5 drops into the canal of the affected ear(s) once daily for 7 days;
Renal Dose
Administration
Contra Indications
Patients with a history of hypersensitivity to ofloxacin, to other quinolones, or to any of the components in this medication.
Precautions
As with other anti-infective preparations, prolonged use may result in over-growth of nonsusceptible organisms, including fungi. If the infection is not improved after one week, cultures should be obtained to guide further treatment.
If otorrhea persists after a full course of therapy, or if two or more episodes of otorrhea occur within six months, further evaluation is recommended to exclude an underlying condition such as cholesteatoma, foreign body, or a tumor.
The systemic administration of quinolones, including ofloxacin at doses much higher than given or absorbed by the otic route, has led to lesions or erosions of the cartilage in weight-bearing joints and other signs of arthropathy in immature animals of various species.
Pregnancy-Lactation
Interactions
Concomitant use of class IA (e.g. quinidine, procainamide) or class III (e.g. amiodarone, sotalol) antiarrhythmic agents may increase risk of QT interval prolongation. Decreased serum and urine concentrations w/ antacids containing Mg, Al or Ca. Additive antibacterial activity w/ aminoglycosides (e.g. amikacin, tobramycin). Corticosteroids may increase risk of severe tendon disorders. Increased risk of CNS stimulation (e.g. seizures) w/ NSAIDs. Higher and prolonged serum theophylline concentrations and increased risk of theophylline-related adverse effects.
Adverse Effects
Side effects of Ofloxacin 0.3% E/E drops :
Ophthalmic:
Transient ocular burning or discomfort following instillation of the solution,Conjunctival hyperemia,Chemical conjunctivitis/keratitis,Foreign body sensation,Blurred vision,Periocular/facial edema,Eye pain,Photophobia,Pruritus,Stinging,Tearing,Dryness,Hemorrhagic conjunctivitis with palpebral edema (rare).
Otic/Aural
>10%
Application site reaction (1-17%)
1-10%
Taste perversion (7%),Pruritus (4%),Dizziness (1%),Earache (1%),Paresthesia (1%),Rash (1%),Vertigo (1%)
<1%
Otorrhagia,Tinnitus,Transient hearing loss,Tremor,Xerostomia,Diarrhea
Mechanism of Action
Ofloxacin is a fluoroquinolone which inhibits bacterial topoisomerase IV and DNA gyrase enzymes required for DNA replication, transcription, repair and recombination. It has activity against a wide range of gram-negative and gram-positive microorganisms.
Note
Ocucin 0.3% Eye manufactured by Sun Pharmaceutical Industries Ltd.. Its generic name is Ofloxacin 0.3% E/E drops. Ocucin is availble in Nepal.
Farmaco Nepal drug index information on Ocucin Eye is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.