Oleanz Forte 10/20 Tablet
Fluoxetine + Olanzapine
10mg + 20mg
Sun Pharmaceutical Industries Ltd.
| Pack size | |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price |
Available as:
Indications
Oleanz Forte 10/20 Tablet is used for:
Depression Associated with Bipolar I Disorder, Treatment of Resistant Depression
Adult Dose
Depression Associated with Bipolar I Disorder
Indicated for acute depressive episodes in bipolar I disorder
Initial: 25 mg/6 mg PO qDay in evening
If needed, may titrate with 25-50 mg fluoxetine/6-12 mg olanzapine; not to exceed 75 mg/18 mg per day
Treatment of Resistant Depression
Indicated for treatment resistant depression (ie, major depressive disorder in patients who do not respond to 2 separate trials of different antidepressants of adequate dose and duration in the current episode)
Initial: 25 mg/6 mg PO qDay in evening
If needed, may titrate with 25-50 mg fluoxetine/6-12 mg olanzapine; not to exceed 75 mg/18 mg per day
Child Dose
Depression Associated with Bipolar I Disorder
Indicated for acute depressive episodes in bipolar I disorder in children and adolescents aged 10-17 years
<10 years: Safety and efficacy not established
10-17 year
Initial: 25 mg/3 mg PO qDay in evening
If needed, may titrate with 25-50 mg fluoxetine/6-12 mg olanzapine; not to exceed 50 mg/12 mg per day
Renal Dose
Administration
Contra Indications
Hypersensitivity to any component
Concomitant thioridazine, pimozide
Coadministration with MAOIs
Precautions
Hypertension, hepatic impairment, slow metabolizers
Conflicting evidence regarding use of SSRIs during pregnancy and increased risk of persistent pulmonary hypertension of the newborn (see Pregnancy)
Pupillary dilation occurs following use of many antidepressant drugs may trigger an angle-closure attack in a patient with anatomically narrow angles who does not have a patent iridectomy
Anaphylactoid reactions (eg, bronchospasm, angioedema, and urticaria) alone and in combination, reported
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Fluoxetine + Olanzapine :
Common
Nausea
Vomiting
Diarrhea
Constipation
Dryness in mouth
Weight gain
Sleepiness
Orthostatic hypotension (sudden lowering of blood pressure on standing)
Dizziness
Muscle rigidity
Restlessness
Tremor
Delayed ejaculation
Anorgasmia (decreased o
Mechanism of Action
Fluoxetine: Inhibits CNS neuron serotonin reuptake with minimal or no effect on norepinephrine or dopamine reuptake; does not bind to alpha-adrenergic, histamine, or cholinergic receptors
Olanzapine: Potent antagonist of dopamine 1-3, histamine H1, serotonin 5-HT2A and 5-HT2C, and alpha1-adrenergic receptors; shows moterate antagonism for 5-HT3, and muscarinic M1-5 receptors; binds to GABA-A, benzodiazepine, and beta-adrenergic receptors
Note
Oleanz Forte 10/20 10mg + 20mg Tablet manufactured by Sun Pharmaceutical Industries Ltd.. Its generic name is Fluoxetine + Olanzapine. Oleanz Forte 10/20 is availble in Nepal.
Farmaco Nepal drug index information on Oleanz Forte 10/20 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.