Opigesic Injection
Pethidine Hydrochloride
50mg
National Healthcare Pvt. Ltd.
| Pack size | 1ml |
|---|---|
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Indications
Opigesic Injection is used for:
Anaesthesia, Postoperative pain, Moderate to severe acute pain, Obstetric analgesia
Adult Dose
Parenteral
Moderate to severe acute pain
Adult: 25-100 mg IM/SC inj or 25-50 mg by slow IV inj repeated after 4 hr.
Obstetric analgesia
Adult: 50-100 mg by IM/SC inj as soon as contractions occur at regular intervals; repeat after 1-3 hr if needed.
Max: 400 mg in 24 hr.
As a preoperative medication
Adult: 25-100 mg IM/SC given 1 hr before surgery.
Postoperative pain
Adult: 25-100 mg IM/SC inj every 2-3 hr if necessary.
Intravenous
Adjunct to anaesthesia
Adult: 10-25 mg by slow IV inj.
Hepatic impairment: Dose reductions may be necessary.
Child Dose
Parenteral
Moderate to severe acute pain
Child:
SC/IM:
2 mth to 12 yr: 0.5-2 mg/kg;
12-18 yr: 20-100 mg. Repeat dose every 4-6 hr if needed.
IV inj: Neonates and children >12 yr: 0.5-1 mg/kg IV inj every 10-12 hr if needed in those up to 2 mth and every 4-6 hr if needed in older children.
12-18 yr: 25-50 mg every 4-6 hr if needed.
Alternatively, >1 mth: Loading dose: 1 mg/kg by IV inj followed by 100-400 mcg/kg/hr via continuous IV infusion adjusted according to response.
As a preoperative medication
Child: 1-2 mg/kg given IM 1 hr before surgery.
Postoperative pain
Child: 0.5-2 mg/kg IM every 2-3 hr if necessary.
Renal Dose
Renal impairment: Dose reductions may be necessary.
Administration
Reconstitution: Dilute with water for inj to a concentration of 5-10 mg/ml.
Contra Indications
Hypersensitivity.
Precautions
May impair ability to drive or operate machinery. Hypovolaemia, CV disease; adrenal insufficiency; biliary tract disorder; CNS depression or coma; history of drug abuse or acute alcoholism; head injury, intracranial lesions, elevated intracranial pressure; hepatic or renal impairment; morbidly obese; prostatic hyperplasia; toxic psychoses; pre-existing respiratory compromise (hypoxia and/or hypercapnia), COPD or other obstructive airway disease; sickle-cell disease; supraventricular tachycardia; thyroid dysfunction. Elderly and debilitated patients. Withdraw gradually. Pregnancy (avoid prolonged use or high doses at term) and lactation.
Pregnancy-Lactation
Pregnancy Category B, D if prolonged use/high doses at term.
Interactions
Increased pethidine metabolite levels with aciclovir, cimetidine, ritonavir. Reduced analgesic effects with phenytoin, barbiturates. Additive sedative and/or respiratory depressive effects with alcohol, barbiturates, benzodiazepines, phenothiazines, TCAs, other CNS depressants.
Potentially Fatal: Increased risk of serotonin syndrome with MAOIs (not be given concurrently or within 14 days of their discontinuation), serotonin agonists, serotonin reuptake inhibitors, sibutramine, TCAs.
Adverse Effects
Side effects of Pethidine Hydrochloride :
Hypotension; fatigue, drowsiness, dizziness, nervousness, headache, restlessness, malaise, confusion, depression, hallucinations, tremors, muscle twitches, increased intracranial pressure, seizure, serotonin syndrome; rash, urticaria; nausea, vomiting, constipation, anorexia, stomach cramps, xerostomia, biliary spasm, paralytic ileus, sphincter of Oddi spasm; ureteral spasms, decreased urination; pain at inj site; weakness; dyspnoea; histamine release, physical and psychological dependence.
Mechanism of Action
Pethidine is a phenylpiperidine derivative opioid analgesic. It acts mainly as mu-receptor agonist. Like most, opioid analgesics, it mimics endogenous opioids by activating opioid receptors in the central and peripheral nervous system. It reduces the release of neurotransmitter substances and also reduces the activity of postsynaptic neurons in the spinal cord thus preventing transmission of pain impulse.
Note
Opigesic 50mg Injection manufactured by National Healthcare Pvt. Ltd.. Its generic name is Pethidine Hydrochloride. Opigesic is availble in Nepal.
Farmaco Nepal drug index information on Opigesic Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.