Ostospray Spray
Salmon Calcitonin
Sun Pharmaceutical Industries Ltd.
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Indications
Ostospray Spray is used for:
Hypercalcaemia, Paget's disease of bone, Postmenopausal osteoporosis.
Adult Dose
Parenteral
Hypercalcemia
Initial dose: 4 IU/kg SC/IM q12hr May increase to 8 IU/kg SC/IM q12hr; may increase up to a maximum 8 IU/kg q6hr if unresponsive
Paget Disease
Initial dose: 100 IU SC/IM qDay
Maintenance: 50 IU/day or 50-100 IU every 1-3 days
Osteoporosis, Postmenopausal
Indicated for the treatment of postmenopausal osteoporosis in women greater than 5 yr postmenopause
100 IU SC/IM every other day with calcium and vitamin D
Nasal Spray:
1 spray (200 IU) qDay, alternate nostrils daily
Child Dose
Safety and efficacy not established
Renal Dose
Administration
Contra Indications
Hypersensitivity.
Precautions
Children <18 yr, renal impairment. Pregnancy, lactation. Serious hypersensitivity reactions, including fatal anaphylaxis, reported; consider skin testing prior to treatment. Hypocalcemia associated with tetany has been reported; ensure adequate intake of calcium and vitamin D
Lactation: excretion in milk unknown/not recommended
Pregnancy-Lactation
Interactions
Concurrent use w/ cardiac glycosides (e.g. digitalis) or Ca-channel blockers requires dosage adjustments of these drugs. May decrease serum concentration of lithium.
Adverse Effects
Side effects of Salmon Calcitonin :
>10%
Rhinitis (12%)
1-10%
Arthralgia (4%),Back pain (5%),Expistaxis (4%),Injection site reactions (10%),Nausea (10%),Headache (3%),Flushing of face or hands (2-5%)
<1%
Abdominal pain,Possible allergic reactions,Appetite decreased,Edema of feet,Eye pain,Feverish sensation,Nausea,Nocturia,Possible local irritative effects in the respiratory tract,Salty taste
Frequency Not Defined
Tremors
Potentially Fatal: Anaphylactic shock.
Mechanism of Action
It inhibits osteoclastic bone resorption and reduces bone turnover. It decreases tubular reabsorption and promotes renal excretion of Ca, Cl, Na, Mg, K and phosphate.
Note
Ostospray Spray manufactured by Sun Pharmaceutical Industries Ltd.. Its generic name is Salmon Calcitonin. Ostospray is availble in Nepal.
Farmaco Nepal drug index information on Ostospray Spray is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.