Ovagen Tablet
Clomiphene Citrate
25mg
Walter Bushnell
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Available as:
Indications
Ovagen Tablet is used for:
Ovulation induction, Female infertility, Polycystic ovary syndrome, Amenorrhea-galactorrhea syndrome, Psychogenic amenorrhea
Adult Dose
Oral
Anovulatory infertility
Adult: 50 mg daily for 5 days starting on the 5th day of menstrual cycle or at any time if there is amenorrhoea. If ovulation does not occur, a 2nd course of 100 mg for 5 days may be used commencing as early as 30 days after the previous therapy. Further treatment may not be recommended if pregnancy has not occurred after a total of 6 treatment cycles.
Child Dose
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Clomiphene citrate is contraindicated during pregnancy, in patients with liver diseases, ovarian cysts, bleeding of undetermined origin, patients with neoplasm of endometrium, hypersensitivity; abnormal bleeding; lactation; uncontrolled thyroid or adrenal dysfunction, patient with an organic intracranial lesions such as pituitary tumor.
Precautions
Clomiphene citrate should be used with caution in the following conditions: longer maintenance therapy, with alcoholic drinks & antidepressants. Polycystic ovaries, evaluate presence of ovarian cyst before each cycle treatment. Uterine fibroids; visual disturbances may develop which will impair ability to drive or operate machinery. There is a minimal chance of multiple pregnancies, about which the patient should be warned.
Lactation: It is not known whether clomiphene is excreted in human milk. Use with caution in nursing women. In some patients, clomiphene may reduce lactation.
Pregnancy-Lactation
Interactions
Decreased response with danazol.
Adverse Effects
Side effects of Clomiphene Citrate :
>10%
Ovarian enlargement (14%),Vasomotor flushing (10%)
1-10%
Abdominal discomfort (6%),Blurred vision (1.5%),Breast discomfort (2%),Nausea/vomiting (2%)
Mechanism of Action
Clomifene inhibits the negative feedback mechanisms of oestrogens in the hypothalamus and pituitary which stimulates the secretion of pituitary gonadotrophic hormones resulting in stimulation of ovulation.
Note
Ovagen 25mg Tablet manufactured by Walter Bushnell. Its generic name is Clomiphene Citrate. Ovagen is availble in Nepal.
Farmaco Nepal drug index information on Ovagen Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.