Oxazep 600 Tablet
Oxycarbazepine
600mg
Magnus Pharma Pvt. Ltd.
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 20 NPR |
Available as:
Indications
Oxazep 600 Tablet is used for:
Partial seizures
Adult Dose
Oral
Partial seizures
Adult: As monotherapy or adjunctive therapy: Initially, 600 mg daily in 2 divided doses, may increase if necessary in max increments of 600 mg daily at wkly intervals.
Maintenance dose: 600-1,200 mg daily or up to 2,400 mg daily in adjunctive therapy or in refractory patients switched from other antiepileptics.
Child Dose
Oral
Partial seizures
Child: >6 yr 8-10 mg/kg daily in 2 divided doses, may increase if necessary in increments of 10 mg/kg daily at wkly intervals.
Maintenance dose: 30 mg/kg daily in adjunctive therapy. Max: 46 mg/kg/day.
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
<30 Initially, 300 mg daily, increased at wkly intervals or longer.
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity. Lactation.
Precautions
Patient carrying the HLA-B1502 allele. Avoid abrupt withdrawal. Severe renal and hepatic impairment. Pregnancy. Patient Counselling May impair ability to drive or operate machinery. Monitoring Parameters Monitor seizure frequency, serum Na, symptoms of CNS depression, hypersensitivity reactions, serum levels of concomitant antiepileptic drugs during titration; periodic thyroid function test and CBC.
Pregnancy-Lactation
Interactions
May increase plasma concentrations of other anticonvulsants (e.g. phenobarbital, phenytoin). May decrease plasma concentrations of OC and Ca channel blockers. Decreased plasma concentrations w/ potent inducers of CYP isoenzymes (e.g. carbamazepine, phenytoin, phenobarbital).
Adverse Effects
Side effects of Oxycarbazepine :
Hyponatraemia; suicidal behaviour or ideation; neuropsychiatric effects (e.g. impaired cognitive or psychomotor performance, somnolence or fatigue, incoordination); dizziness, somnolence, diplopia, fatigue, nausea, vomiting, ataxia, abnormal vision, abdominal pain, tremor, dyspepsia, abnormal gait, hypothyroidism. Rarely, pancytopenia, agranulocytosis, leucopenia.
Potentially Fatal: Stevens-Johnson syndrome, toxic epidermal necrolysis; anaphylaxis, angioedema; Drug Reaction w/ Eosinophilia and Systemic Symptoms (DRESS).
Mechanism of Action
Oxcarbazepine and monohydroxy derivative (MHD) block voltage-sensitive Na channels, stabilising hyperexcited neuronal membranes, inhibiting repetitive firing, and decreasing the propagation of synaptic impulses. These actions are believed to prevent the spread of seizures. Oxcarbazepine and MHD also increase K conductance and modulate the activity of high-voltage activated Ca channels.
Note
Oxazep 600 600mg Tablet manufactured by Magnus Pharma Pvt. Ltd.. Its generic name is Oxycarbazepine. Oxazep 600 is availble in Nepal.
Farmaco Nepal drug index information on Oxazep 600 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.