P-Clox Capsule

Amoxicillin + Cloxacilin

250mg + 250mg

Genetica Laboratory Pvt. LTd.

Pack size
Dispensing mode
Source
Agent
Retail Price	9.00 NPR

Available as:

125mg + 125mg - Suspension

Indications

P-Clox Capsule is used for: Susceptible infections

Adult Dose

Oral Susceptible infections Adult: Per capsule contains amoxicillin 250 mg and cloxacillin 250 mg: 2-4 caps tid. Parenteral Susceptible infections Adult: Per vial contains amoxicillin 250 mg and cloxacillin 250 mg: 1-2 vials every 6-8 hr. Dose may be given via IM/IV.

Child Dose

Parenteral Susceptible infections Child: Per vial contains amoxicillin 250 mg and cloxacillin 250 mg: 1 mth-2 yr: 0.25-0.5 vial every 6-8 hr; 2-10 yr: 0.5-1 vial every 6-8 hr. Dose may be given via IM/IV.

Renal Dose

Administration

Contra Indications

Hypersensitivity to penicillins.

Precautions

Allergy to cephalosporins, infectious mononucleosis, neonates with jaundice, H/o convulsions, lactation.

Pregnancy-Lactation

Interactions

Failure of OC may occur, loss of potency of cloxacillin in soln. reported with erythromycin, gentamicin, kanamycin, colistin, oxytetracycline, chlorpromazine, Vit.C, & polymyxin B sulphate. Products containing cloxacillin should not be added to IV lipids, blood products, protein hydrolysates or other proteinaceous fluids. Chloramphenicol & tetracycline antagonise bactericidal effect of penicillins. Probenecid prolongs serum drug concentration; Sulfonamides & aspirin inhibit serum protein binding of cloxacillin, thereby increasing serum-free drug levels. Potentially Fatal: None reported.

Adverse Effects

Side effects of Amoxicillin + Cloxacilin : GI upsets, rash, urticaria, neutropenia, neurotoxicity, agranulocytosis (rarely), increased incidence of phlebitis with IV use. Potentially Fatal: Rarely anaphylactic shock; pseudomembranous colitis.

Mechanism of Action

Amoxicillin is bactericidal against non β-lactamase producing gm+ve organisms and selected gm-ve pathogens. Cloxacillin is a beta-lactamase resistant penicillin active against gm+ve organisms including beta-lactamase (penicillinase) producing strains of Staphylococci. It is highly active against Staph aureus, Strep pyogenes, Strep viridans and Strep pneumoniae. Also effective against penicillinase producing gonococci and against N meningitidis and H influenzae.

Note

P-Clox 250mg + 250mg Capsule manufactured by Genetica Laboratory Pvt. LTd.. Its generic name is Amoxicillin + Cloxacilin. P-Clox is availble in Nepal. Farmaco Nepal drug index information on P-Clox Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Amoxicillin + Cloxacilin :

Capsule

Peri-AC

Deurali Janta Pharmaceuticals Pvt. Ltd.

Capsule

Myclox ^{250mg + 250mg}

S.R. Drug Laboratories Pvt. Ltd.

Syrup

Myclox ^{250mg + 125mg}

S.R. Drug Laboratories Pvt. Ltd.

Suspension

P-Clox ^{125mg + 125mg}

Genetica Laboratory Pvt. LTd.

Capsule

Peri-AC ^{250mg + 250mg}

Deurali Janta Pharmaceuticals Pvt. Ltd.