Paaz Tablet

Alprazolam
2.5mg
Nepal Pharmaceuticals Pvt. Ltd.
Pack size 1
Dispensing mode
Source
Agent
Retail Price 2.25 NPR

Available as:

Indications

Paaz Tablet is used for: Anxiety disorders, Panic disorders, Nausea due to chemotherapy

Adult Dose

Oral Short-term management of anxiety Adult: 0.25-0.5 mg tid, increased to 3-4 mg daily if necessary. Elderly: Initially, 0.25 mg bid/tid. Panic attacks Adult Immediate-release 0.5 mg PO q8hr; may increase q3-4Days by ?1 mg/day Average dose: 5-6 mg/day PO May require up to 10 mg/day PO divided q8hr Extended-release 0.5-1 mg PO qDay; may increase q3-4Days by <1 mg/day Average dose: 3-6 mg PO qDay Anxiety Associated With Depression 1-4 mg/day PO divided q8hr Hepatic impairment: Avoid in severe impairment.

Child Dose

<18 years old: Not recommended

Renal Dose

Renal impairment: Use caution; not studied

Administration

Administration May be taken with or without food. Side effects eg sleepiness/drowsiness may be reduced if taken immediately after meals.

Contra Indications

Acute narrow-angle glaucoma, preexisting CNS depression or coma, resp depression, acute pulmonary insufficiency or sleep apnoea; severe hepatic impairment; pregnancy, lactation.

Precautions

Dosage reduction or gradual withdrawal. Dependence. Geriatric or debilitated patients. Muscle weakness, impaired hepatic or renal function; arteriosclerosis; obesity; depression particularly suicidal tendency; chronic pulmonary insufficiency. May impair ability to drive or operate machinery. Children <18 yr. Lactation: Enters breast milk/not recommended

Pregnancy-Lactation

Interactions

Potentiates action of alcohol and CNS depressants. Reduced conc with cigarette smoking by 50%. Potentially Fatal: Cimetidine and fluoxetine reduce the clearance of alprazolam. Alprazolam enhances activity of imipramine and desipramine.

Adverse Effects

Side effects of Alprazolam : >10% (4 mg dose) Drowsiness (41%),Depression (10-15%),Headache (10-15%),Constipation (10-15%),Diarrhea (10-15%),Dry mouth (10-15%) >10% (10 mg dose) Drowsiness (77%),Impaired coordination (40-50%),Increased appetite (30-35%),Fatigue (30-35%),Memory impairment (30-35%),Irritability (30-35%),Decreased salivation (30-35%),Cognitive disorders (20-30%),Insomnia (20-30%),Dcreased appetite (20-30%),Headache (20-30%),Lightheadedness (20-30%),Dysarthria (20-30%),Diarrhea, constipation, and nausea/vomiting (20-30%),Weight change (20-30%),Nasal congestion (15-20%),Decreased or increased libido (10-15%),Menstrual disorder (10-15%),Difficult micturition (10-15%) 1-10% (4 mg dose) Tachycardia (5-10%),Confusion (5-10%),Insomnia (5-10%),Nausea/vomiting (5-10%),Blurred vision (5-10%),Nasal congestion (5-10%),Hypotension (1-5%),Syncope (1-5%),Akathisia (1-5%),Dizziness (1-5%),Increased salivation (1-5%),Nervousness (1-5%),Tremor (1-5%),Weight change (1-5%) 1-10% (10 mg dose) Increased salivation (5-10%),Talkativeness (1-5%),Incontinence (1-5%) Potentially Fatal: Blood dyscrasias.

Mechanism of Action

Alprazolam has anxiolytic, muscle-relaxant, anticonvulsant, antidepressant and sleep-modifying effects. It binds to the ? aminobutyric acid (GABA)-specific sites throughout the CNS, leading to an increase in the inhibitory effect of GABA on neuronal excitability. Increased neuronal permeability to chloride ions thus results in hyperpolarisation and stabilisation.

Note

Paaz 2.5mg Tablet manufactured by Nepal Pharmaceuticals Pvt. Ltd.. Its generic name is Alprazolam. Paaz is availble in Nepal. Farmaco Nepal drug index information on Paaz Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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