Pantoloc Tablet

Pantoprazole Sodium Sesquihydrate
40 mg
Curex Pharmaceuticals Pvt. Ltd.
Pack size 100's
Dispensing mode
Source
Agent
Retail Price 8.00 NPR

Available as:

Indications

Pantoloc Tablet is used for: Peptic ulcer disease, H. pylori infection, Gastro-oesophageal reflux disease, Zollinger-Ellison syndrome, Oesophagitis, Acid-related dyspepsia, NSAID-associated ulceration, ulcer resistant to H2 receptor antagonists, Gastrointestinal (GI) bleeding from stress, Prophylaxis for acid aspiration syndrome during induction of anaesthesia

Adult Dose

Erosive Esophagitis Associated With GERD Treatment: 40 mg PO qDay for 8-16 weeks Maintenance of healing: 40 mg PO qDay Alternatively, 40 mg IV qDay for 7-10 days Short-term Treatment of GERD Oral therapy inappropriate or not possible: 40 mg IV infusion over 15 minutes qDay for 7-10 days; switch to PO once patient able to swallow Zollinger-Ellison Syndrome 40 mg PO qDay; up to 240 mg/day administered in some patients 80 mg IV infusion q8-12hr up to 7 days; switch to PO once patient able to swallow Peptic Ulcer Disease Duodenal ulcer: 40 mg PO qDay for 2-4 weeks Gastric ulcer: 40 mg PO qDay for 4-8 weeks Elderly: No dosage adjustment needed. Hepatic impairment: Max: 20 mg/day or 40 mg on alternate days.

Child Dose

Erosive Esophagitis Associated With GERD <5 years: Safety and efficacy not established >5 years 15 kg to <40 kg: 20 mg PO qDay for up to 8 weeks 40 kg or greater: 40 mg PO qDay for up to 8 weeks

Renal Dose

Renal impairment: No dosage adjustment needed.

Administration

Controlled-release: Should be taken on an empty stomach. Take 1 hr before meals. Swallow whole, do not chew/crush. Normal release: May be taken with or without food. IV Preparation GERD with a history of erosive esophagitis 15-min infusion: Reconstitute with 10 mL NS, THEN further dilute with 100 mL D5W, NS, or LR to final concentration of 0.4 mg/mL Zollinger-Ellison syndrome 15-min infusion: Reconstitute each vial with 10 mL NS, THEN Combine 2 vials and further dilute with 80 mL D5W, NS, or LR to total volume of 100 mL (concentration 0.8 mg/mL) 2-min injection: Reconstitute with 10 mL NS to final concentration of 4 mg/mL IV Administration Infuse over 15 min no more than 3 mg/min (7 mL/min) for GERD and 6 mg/min (7 mL/min) for pathologic hypersecretory conditions

Contra Indications

Concomitant use w/ rilpivirine, atazanavir and nelfinavir. Lactation.

Precautions

Gastric malignancy should be ruled out. Consider Zn++ supplementation during IV therapy in patients who are prone to Zn++ deficiency. Pregnancy. Monitoring Parameters Monitor Mg levels prior to initiation and periodically during prolonged use. Lactation: Not known whether pantoprazole is distributed into breast milk; not recommended

Pregnancy-Lactation

Interactions

Increased risk of digoxin-induced cardiotoxic effects. Increased risk of hypomagnesaemia w/ diuretics. May increase INR and prothrombin time of warfarin. May increase serum concentration of methotrexate and saquinavir. Delayed absorption and decreased bioavailability w/ sucralfate. Decreased absorption of ketoconazole, itraconazole. Potentially Fatal: May decrease serum levels and pharmacological effects of rilpivirine, atazanavir and nelfinavir.

Adverse Effects

Side effects of Pantoprazole Sodium Sesquihydrate : 1-10% Headache (>4%),Abdominal pain (4%),Facial edema (<4%),Generalized edema (<2%),Chest pain (4%),Diarrhea (4%),Constipation (<4%),Pruritus (4%),Rash (4%),Flatulence (<4%),Hyperglycemia (1%),Nausea (1%),Vomiting (>4%),Photosensitivity (<2%) Frequency Not Defined Angioedema,Atrophic gastritis,Anterior ischemic optic neuropathy,Hepatocellular damage leading to hepatic failure,Interstitial nephritis,Pancreatitis,Pancytopenia,Rhabdomyolysis,Risk of anaphylaxis,Stevens-Johnson syndrome,Fatal toxic epidermal necrolysis,Erythema multiforme

Mechanism of Action

Pantoprazole is a substituted benzimidazole, and also known as PPI due to its property to block the final step of acid secretion by inhibiting H+/K+ ATPase enzyme system in gastric parietal cell. Both basal and stimulated acid are inhibited.

Note

Pantoloc 40 mg Tablet manufactured by Curex Pharmaceuticals Pvt. Ltd.. Its generic name is Pantoprazole Sodium Sesquihydrate. Pantoloc is availble in Nepal. Farmaco Nepal drug index information on Pantoloc Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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