Pasitrex Ointment
Calcipotriol topical
Sun Pharmaceutical Industries Ltd.
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Indications
Pasitrex Ointment is used for:
Mild to moderate plaque psoriasis, Scalp psoriasis
Adult Dose
Topical/Cutaneous
Mild to moderate plaque psoriasis
Adult: As 0.005% cream/oint: Apply a thin layer and rub in gently and completely to the affected area 1-2 times daily. Max: 100 g/wk; if used together w/ scalp soln, 5 mg of the drug per wk (e.g. cream/oint 60 g w/ scalp soln 40 mL or cream/oint 40 g w/ scalp soln 60 mL).
Scalp psoriasis
Adult: As 0.005% soln: Apply and rub in gently and completely to the affected area bid. Avoid contact w/ the forehead or uninvolved scalp margin.
Max: 60 mL/wk; if used together w/ cream/oint, 5 mg of the drug per wk (e.g. cream/oint 60 g w/ scalp soln 40 mL or cream/oint 40 g w/ scalp soln 60 mL).
Hepatic impairment: Severe: Contraindicated.
Child Dose
Topical/Cutaneous
Mild to moderate plaque psoriasis
Child: As 0.005% oint: Apply bid. Max: 6-12 yr 50 g/wk; >12 yr 75 g/wk. Max duration: 8 wk.
Renal Dose
Renal impairment: Severe: Contraindicated.
Administration
Contra Indications
Hypercalcaemia, Ca metabolism disorder. Acute psoriatic eruptions (scalp soln). Severe renal or hepatic impairment.
Precautions
Patient w/ erythrodermic exfoliative psoriasis, generalised pustular psoriasis. Pregnancy and lactation. Patient Counselling Avoid application to the face, eyes, or mucous membranes. Avoid exposure to natural or artificial sunlight. Monitoring Parameters Monitor serum Ca.
Pregnancy-Lactation
Interactions
Inactivated by salicylic acid externals.
Adverse Effects
Side effects of Calcipotriol topical :
Skin irritation, burning, itching, erythema, and dryness; eczema, contact dermatitis, aggravated psoriasis; hypercalcaemia, hypercalciruria. Rarely, skin atrophy, hyperpigmentation, photosensitivity.
Mechanism of Action
Calcipotriol, a synthetic vit D3 derivative, is an antipsoriatic agent. It binds to vit D receptors to induce differentiation and supress proliferation of keratinocytes.
Note
Pasitrex Ointment manufactured by Sun Pharmaceutical Industries Ltd.. Its generic name is Calcipotriol topical. Pasitrex is availble in Nepal.
Farmaco Nepal drug index information on Pasitrex Ointment is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.