Persantin Tablet
Dipyridamole
100mg
Cadila Pharmaceuticals Limited.
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Available as:
Indications
Persantin Tablet is used for:
Stroke, Thromboembolism, Transient ischaemic attack
Adult Dose
Oral
Thromboembolism Prophylaxis Post-Cardiac Valve Replacement
Adult: 75-100 mg PO q6hr as adjunct to warfarin
Child Dose
Oral
Thromboembolism Prophylaxis Post-Cardiac Valve Replacement
Child: 3-6 mg/kg/day PO divided q6-8hr
Renal Dose
Administration
Should be taken on an empty stomach. Take on an empty stomach 1 hr before meals. May be taken w/ meals to reduce GI discomfort.
Contra Indications
Hypersensitivity. Peptic ulcer.
Precautions
In patients with rapidly worsening angina, subvalvular aortic stenosis, haemodynamic instability associated with recent MI or coagulation disorders esp when given IV during myocardial imaging. Hypotension, unstable angina, aortic stenosis. Pregnancy and lactation. Safety and efficacy are not established in childn < 12 yrs.
Lactation: enters breast milk; use with caution
Pregnancy-Lactation
Interactions
Aminophylline may reverse vasodilatation effect. Useful combination with aspirin in prevention of thromboembolism. Efficacy reduced by concurrent admin of antacids. Concurrent use may increase the cardiotoxic effects of adenosine.
Potentially Fatal: Potentiates effects of oral anticoagulants and antiarrhythmic agents.
Adverse Effects
Side effects of Dipyridamole :
>10%
Chest pain (20%),Abnormal ECG (15.9%),Dizziness (12%)
1-10%
ST-T changes (7.5%),Abdominal discomfort, oral (6.1%),Extrasystole (5%),Flushing (3.4%),Generalized pain (2.6%),Headache, oral (2.3%)
Frequency Not Defined
Myocardial infarction (rare),Ventricular arrhythmia (rare),Bronchospasm (rare),Dyspnea
Mechanism of Action
Dipyridamole causes an accumulation of adenosine, adenine nucleotides and cAMP by inhibiting the activity of adenosine deaminase and phosphodiesterase thus inhibiting platelet aggregation and may cause vasodilation.
Note
Persantin 100mg Tablet manufactured by Cadila Pharmaceuticals Limited.. Its generic name is Dipyridamole. Persantin is availble in Nepal.
Farmaco Nepal drug index information on Persantin Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.