Phenpres Injection

Phenylephrine
Neon Laboratories Ltd
Pack size
Dispensing mode
Source
Agent
Retail Price 396.80 NPR

Indications

Phenpres Injection is used for: Nasal congestion

Adult Dose

Oral Nasal congestion Adult: 10-20 mg every 4 hr, max 60 mg daily

Child Dose

Oral Nasal congestion 6-12 yr: 10 mg every 4 hr

Renal Dose

Administration

Should be taken with food.

Contra Indications

Hypertension, ventricular tachycardia. Oral: use with or within 14 days of MAOI therapy. Ophthalmic: narrow-angle glaucoma.

Precautions

Severe hyperthyroidism, severe ischaemic heart disease, DM, prostatic hyperplasia. Rebound congestion in prolonged or excessive use of nasal drops. Use 10% eye drops in extreme caution in infants, elderly, cardiac disease, significant hypertension, advanced arteriosclerosis. Pregnancy and lactation. Over-the-counter cough and cold medications should not be used in infants and children <2 yr.

Pregnancy-Lactation

Interactions

May increase hypertensive effect of beta-blockers (nonselective); MAOI potentiate hypertension; methyldopa and TCA can increase the pressor response.

Adverse Effects

Side effects of Phenylephrine : Anxiety, reflex bradycardia, tachycardia, arrhythmias, headache, cold extremities/gangrene, hypertension, nausea, vomiting, sweating, weakness, fear, restlessness, insomnia, confusion, irritability, psychotic states, dyspnoea, anorexia, palpitations, extravasation causing tissue necrosis and sloughing, mydriasis, difficulty in micturition and urinary retention, piloerection, increased salivation, hyperglycaemia, lactic acidosis. Ophthalmic solutions may liberate pigment granules from the iris, corneal clouding/damage. Potentially Fatal: Increase in cardiac contractility, which may lead to angina or cardiac arrest; severe hypertension leading to cerebral haemorrhage or pulmonary oedema.

Mechanism of Action

Phenylephrine is a sympathomimetic with mainly direct effects on alpha-adrenergic receptors and weak beta-adrenergic activity. It causes vasoconstriction of the arterioles of the nasal mucosa and conjunctiva; activates the dilator muscle of the pupil to cause contraction; produces vasoconstriction of arterioles in the body and produces systemic arterial vasoconstriction.

Note

Phenpres Injection manufactured by Neon Laboratories Ltd. Its generic name is Phenylephrine. Phenpres is availble in Nepal. Farmaco Nepal drug index information on Phenpres Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Phenylephrine :